… defined precursor frequency as the number of naive CD8 T cells … 100 cells/spleen. It has
been estimated that an adult uninfected mouse contains between 2–4 × 10 7 naive CD8 + T cells…

… CD62L hi memory cells. Thus, initial endogenous precursor frequencies were surprisingly
diverse … response characteristics but also controlled memory CD8 + T cell lineage decisions. …

… -tg T cell precursor frequencies cause a more global alteration in T cell behavior has not
been determined. Here, we directly addressed the impact of TCR-tg precursor frequency on the …

… a frequency of GP33-specific naïve CD8 + T cell precursors. For VV, the in vivo LDA calculates
about 13,850 responsive CD8 + T cells … assay estimated 1,070 CD8 + T cells specific for …

… 100-fold differences in T-cell precursor frequency across the different naive antigen-specific
CD8 + T cells, but surprisingly, there was a tight range of frequencies among humans for a …

… model to measure the precursor frequency of naive CD4 + T cells. This approach also has …
CD8 T cells have a similar precursor frequency, of ∼10 −5 . After virus infection, CD4 + T cell …

… Given the finding that a high precursor frequency of CD8 + T cells was critically important in
… define the effects of altered CD8 + T cell precursor frequency on the programmed expansion …

… We show that cells primed at precursor frequencies … CD8 + T cell precursor frequency to
tumor immunity and autoimmunity. Transferring optimized numbers of naive tumor-specific T cells…

… T cell proliferation in the pancreatic lymph nodes and the rate of tolerance of HA-specific CD8
+ T cells… CD8 + T cells in the pancreatic lymph nodes is a precursor of peripheral tolerance. …

… Effect of MHC class I diversification on influenza epitope-specific CD8+ T cell precursor
frequency … Endogenous naive CD8+ T cell precursor frequency regulates primary and memory …