… We also found that CD8 + T cells are predominantly … Isolation of CD8 + T cells from the
lesional skin of early active … and together strongly suggest that CD8 + T cells contribute to SSc …

… CD8 + T cells (Fig. 1a). While very little IL-4 production was detected in the culture supernatants
of CD4 + and CD8 + T cells … in CD4 and/or CD8 T cells by intracellular cytokine staining (…

… subtype of CD4 + CD8 + double-positive T cells in the skin of … + CD8 + double-positive T
cells, CD8 + single-positive T cells … This increase in CD8 + single-positive T-cell IL-4 secretion …

… circulating CD8 + T cells to migrate to sites of evolving scleroderma … in scleroderma tissue
to attract mononuclear blood cells [… ahead with IFNγ production in CD8 + T cells, which was in …

… We purified CD8+CD45RA+ T cells from total CD8+ T cells isolated from SSc patients and …
-13+ cells in the CD45RA+ (naive and effector) and CD45RA– (memory) CD8+ T cell subsets (…

… of IL-4–producing CD8+ T cells have been observed in the skin of SSc … CD8+ T cells in
patients with SSc, as well as in their cytokine production ability compared to that of CD8+ T cells …

In recent years, accumulating evidence suggest that regulatory T cells (Tregs) are of
paramount importance for the maintenance of immunological self-tolerance and immune …

… Here we analyzed the role of CD8 + CD28 – T cells in the pathogenesis of systemic sclerosis
(… Thus, our findings indicate that CD8 + CD28 – T cells represent a pathogenic T-cell subset …

… In this study, we first purified effector memory CD8 + T cells by cell sorting and subsequently
performed cDNA microarray analysis of the sort-purified effector memory CD8 + T cells from …

… T cells in SSc skin are derived from the CD8+ SP T cells in the sclerotic skin lesions, because
DP T cells used a set of TCRs completely different from those used by the CD8+ SP T cells. …