… ) to pathogens that induce CD8 T cell responses. Thus, for many ofthe pathogens discussed
in this review, CD8 T cell … CD8 T cells express a range of effector molecules that mediate …

… clinical trials of monoclonal antibodies specifically against CD4 + T cells, or the polarizing …
antibodies that deplete all T cells. Here, we review the evidence that CD8 + T cells play a role …

… Thus, myelin-specific CD4 T cells are likely to be one of several important mechanisms that
… of pathogenic CNS-reactive CD8 T cells and the molecular mechanisms these lymphocytes …

… We find that in all four cases the expansion of the CD8 T cells is dependent on direct IFN-I …
depending on the specific pathogens. The greatest expansion of the CD8 T cells, as well as …

… infected target T cells and potentially also the intracellular pathogen (3). (B) Pathogen specific
… Tregs can inhibit both proliferation and cytokine production of Th cells, thereby indirectly …

… CD8 T cells has highlighted a diversity of functional responses. Like CD4 T cells, CD8 T cells
differentiate into multiple … CD8 Tc1 cells comprise the canonical CTL subset, producing IFNγ…

… the role of CD8 + T cells in CNS autoimmunity for several reasons. First, CD8 + T cell clones
specific … Third, the ability of CD8 + myelin-specific T cells to function as effector cells in CNS …

… for killing cells infected with viruses or other intracellular pathogens. However, CD8+ T cells
… produce various cytokines suggests additional functions. The recent discovery of subsets of …

… artery plaques revealed CD8 + T cell infiltration in atherosclerotic lesions [31]. We could
recently corroborate abundant CD8 + T cell infiltrates at various locations in atherosclerotic …

… CD8 + T cell activation may be an important component of the innate IFN-γ response against
intracellular pathogens… in CD8 + than CD4 + T cells (41), consistent with the T cell subset …