… in HCV replication and immune response to HCV infection. In … knowledge on the involvement
of CD81 in HCV infection. … In this study, low CD81 expression level affected slightly HCV …

… To evaluate whether amino acids at positions 178 and 181 are critical for HCV infection,
we expressed CD81 molecules altered at these residues. The rat residues, either singly or in …

… that susceptibility to HCV infection depends on a critical quantity of CD81 molecules. While
infection is restricted in cells expressing very small amounts of CD81, susceptibility rapidly …

… fact that CD81 is not a mere attachment factor for HCV but actively promotes infection by
triggering … From these data, we can speculate that expression of CD81 on the cellular surface …

… , CD81 is involved in HCVser infection of human hepatocytes, and comparative studies of
HCVser versus JFH1/HCVcc infection of … To reduce CD81 expression, hepatocytes were …

… We next examined the requirement of CD81 for HIV-HCV infection of human … CD81 expression
in Huh-7.5 cells is required for HCV pseudotype infection, we silenced CD81 expression …

… from HCV-infected individuals. Furthermore, expression of the putative HCV receptor CD81
on … subpopulation of PBMC is susceptible to HCV infection and is undetectable in our assay. …

… was consequently restored to HCV infection permissiveness. … CD81 silencing RNA into a
CD81-positive cell clone. In conclusion, CD81 expression is an important determinant of HCV …

… an HCV infectious cell culture and HCV replicon cells of genotypes 1b and 2a. We also showed
that CD81 expression … Our data suggest that CD81 has dual functions in HCV infection: a …

… Factors that influence CD81 expression may … to CD81 during HCV infection can alter the
expression of CD81. The examination of CD81 expression levels in patients infected with HCV …