… We identified an ortholog of the cell division control protein 50 (Cdc50) family of the …
We found that a cdc50 mutant in C. neoformans was defective for survival in macrophages, …

… To confirm the caspofungin sensitivity of the cdc50Δ mutant in C. neoformans, we deleted the
entire CDC50 open … gene family, and our study shows that it shares several properties with …

… , as loss of the CDC50 gene sensitizes C. neoformans to caspofungin, a member of the
echinocandins class. We sought to elucidate how Cdc50 facilitates caspofungin resistance by …

… These results identify C. neoformans Cdc50 as an essential subunit for Apt1-3p and provide
… β-subunits (CDC50, LEM3, and CRF1) [23], only one gene of this family, previously named …

… forms a heterodimeric complex with the C. neoformans Cdc50 protein. This association is
required … cerevisiae, the Cdc50 family members ScCdc50p, ScLem3p, and ScCrf1p form stable …

… We discovered that Cdc50 interacts with the … mechanosensitive channels of small
conductance-like, or MSL) protein family, … -MSL family, we propose that calcium signaling and [Ca …

… the loss of Cdc50 led to increased sensitivity to caspofungin in Cryptococcus neoformans. …
[50], who reported that losing Lem3, a Cdc50 family protein, led to alterations in the electronic …

… virulence factors has been well studied in Cryptococcus neoformans (Hu and Kronstad
2010; Rizzo et al. 2014; Huang et al. 2016; Hu et al. 2017). Cdc50 is the non-catalytic subunit of …

… neoformans CDC50, encoding a lipid flippase responsible for the translocation of phospholipids
from the exocytoplasmic to the cytoplasmic leaflet, was shown to be important for CAS …

… neoformans CDC50 mutants were hypersensitive to FLC (16 to 1 μg/ml) and also displayed
… gene encoding an unknown MFS transporter, a family of proteins that has been implicated in …