The structure of the T cell antigen receptor

GA Bentley, RA Mariuzza - Annual review of immunology, 1996 - annualreviews.org
… While we may hope for structural analyses of the TCR/antigencomplex in the future, the
present results provide a base for designing furtherexperiments to probe the nature of TCR/…

[PDF][PDF] Structure, func-tion, and serology of the T cell antigen receptor com-plex

JP Allison, LL Lanier - Ann. Rev. Immunol, 1987 - researchgate.net
… Both antibody inhibition experiments and functional analysis of MHC restriction of T-cell
clones support the concept that these molecules are primarily involved in MHC interactions (177-…

An evolutionary and structural perspective on T cell antigen receptor function

B Malissen - Immunological reviews, 2003 - Wiley Online Library
… ), and of recent structural data on the ligand‐binding subunits of these receptors, we use
these … of occupancy of the binding site of the T cell antigen receptor (TCR) is conveyed to the …

Structurefunction analysis of the extracellular domains of the Duffy antigen/receptor for chemokines: characterization of antibody and chemokine binding sites

C Tournamille, A Filipe, K Wasniowska… - British journal of …, 2003 - Wiley Online Library
antibodies characterized by PEPSCAN analysis and K562-transfected alanine substitution
mutant cells to … residues that appear to be functional determinants of the CXCL-8 binding site. …

[PDF][PDF] T cell antigen receptor: structure, assembly and function

AM Weissman, JS Bonifacino, RD Klausner… - Year …, 1989 - researchgate.net
… In summary, it appears that there is good correlation between mitogenic signals and TCR
phosphorylation even if the signalling molecule is distinct from the TCR. The question that …

Functional analysis of the antigen binding site on the T cell receptor alpha chain.

EA Nalefski, S Kasibhatla, A Rao - The Journal of experimental …, 1992 - rupress.org
antigens/MHC by the antigen receptor expressed on the T cell clone D5 is similar to recognition
by other TCR: D5 cells … D5 cells recognize antigens in an MHC-restricted manner; that is, …

On the structure of the T-cell receptor for antigen

U Krawinkel, M Cramer, C Berek… - Cold Spring Harbor …, 1977 - symposium.cshlp.org
… nature of the T-cell receptor is discussed on the basis of two … sis of the functional antigen
receptor of T helper cells. The … We therefore analyzed the requirements for T-helper-cell priming …

The B-cell antigen receptor complex: structure and signal transduction

CM Pleiman, D D'Ambrosio, JC Cambier - Immunology today, 1994 - cell.com
… As noted earlier, the antigen receptor on immature and mature B cells comprises a clonally
distributed membrane-bound sIg that is noilcovale~itly associated with disulfide-linked Ig-oe …

Structure-function relationships of chimeric antigen receptors in acute T cell responses to antigen

H Xu, AE Hamburger, JY Mock, X Wang, AD Martin… - Molecular …, 2020 - Elsevier
Chimeric antigen receptors (CARs) and their parent signaling molecule, the T cell receptor (TCR),
are fascinating proteins of increasing relevance to disease therapy. Here we use a …

Genetic analysis of B cell antigen receptor signaling

T Kurosaki - Annual review of immunology, 1999 - annualreviews.org
… signaling complex that contributes to cell fatedecisions is the B cell antigen receptor (BCR).
Data from knockout experimentsin cell lines and mice have revealed distinct functions for the …