The B-cell antigen receptor complex

M Reth, J Hombach, J Wienands, KS Campbell… - Immunology today, 1991 - cell.com
… may not be a competent transducer comes from studies of signal transduction by mutant
mlgM molecules that have conservative residue changes in the H chain transmembrane domain

[PDF][PDF] The T cell antigen receptor: insights into organelle biology

RD Klausner, J Lippincott-Schwartz… - Annual review of cell …, 1990 - researchgate.net
… They all possess N-termina1 1eader sequences and have a predicted topology with respect
to the membrane that includes a single transmembrane domain with the amino terminus …

The B-cell antigen receptor complex: structure and signal transduction

CM Pleiman, D D'Ambrosio, JC Cambier - Immunology today, 1994 - cell.com
… As noted earlier, the antigen receptor on immature and mature B cells comprises a clonally
… Point mutations in this polar region of the transmembrane domain of slgM have also been …

[HTML][HTML] Assembly and function of the T cell antigen receptor. Requirement of either the lysine or arginine residues in the transmembrane region of the alpha chain.

RS Blumberg, B Alarcon, J Sancho… - Journal of Biological …, 1990 - Elsevier
… In summary, the arginine and lysine residues in the transmembrane region of the TCR (Y
chain appear to play an important role in assembly and cell surface presentation of the TCR. …

… antigen response of chimeric antigen receptors harboring the CD3ζ transmembrane domain is dependent upon incorporation of the receptor into the endogenous …

JS Bridgeman, RE Hawkins, S Bagley… - The Journal of …, 2010 - journals.aai.org
… used in MFEζ is shown with the transmembrane domain highlighted (A). Numbers above
refer to the amino acids relative to the transmembrane domain and are those used in this paper…

CART: a conserved antigen receptor transmembrane motif

KS Campbell, BT Bäckström, G Tiefenthaler… - seminars in …, 1994 - Elsevier
transmembrane sequences of 72 vertebrate antigen receptor (… a Conserved Antigen Receptor
Transmembrane (CART) … , modeling the antigen receptor transmembrane domain in an o …

T-cell antigen receptor transmembrane peptides modulate T-cell function and T cell-mediated disease

N Manolios, S Collier, J Taylor, J Pollard, LC Harrison… - Nature medicine, 1997 - nature.com
… , RD Transmembrane helical interactions and the assembly of the T cell antigen receptor
assembly and probable structure of the T-cell antigen receptor. EMBOJ. 10, 1643–1651 (1991). …

[HTML][HTML] Hinge and transmembrane domains of chimeric antigen receptor regulate receptor expression and signaling threshold

K Fujiwara, A Tsunei, H Kusabuka, E Ogaki… - Cells, 2020 - mdpi.com
… To clarify the role of hinge and transmembrane domains in CAR and CAR-T cell … and
antigen-specific activity on CAR-T cells. First, we created a basic CAR with hinge, transmembrane, …

Transmembrane helical interactions: zeta chain dimerization and functional association with the T cell antigen receptor.

T Rutledge, P Cosson, N Manolios… - The EMBO …, 1992 - embopress.org
… In this study, we demonstrate that it is the transmembrane domain of ~… transmembrane
residue in this process. In addition, we demonstrate the critical role of the transmembrane region

[HTML][HTML] The T cell antigen receptor α transmembrane domain coordinates triggering through regulation of bilayer immersion and CD3 subunit associations

KN Brazin, RJ Mallis, A Boeszoermenyi, Y Feng… - Immunity, 2018 - cell.com
… of cellular activation following αβT cell antigen receptor (TCR… the TCRα subunit transmembrane
(TM) domain revealing a … during pMHC ligation initiate T cell activation via a dissociative …