Modulation of endothelial cell apoptosis by heme oxygenase-1-derived carbon monoxide
… heme oxygenase-1 (HO-1) acts in a cytoprotective manner in a variety of cell types, including
in endothelial cells … HO-1 expression protects EC from undergoing apoptosis. We have also …
in endothelial cells … HO-1 expression protects EC from undergoing apoptosis. We have also …
[HTML][HTML] Mechanisms of cell protection by heme oxygenase-1
… We found that HO-1 protects endothelial cells from undergoing TNF-mediated apoptosis (75),
an effect later expanded to many other proapoptotic agonists (76) as well as …
an effect later expanded to many other proapoptotic agonists (76) as well as …
Carbon monoxide generated by heme oxygenase 1 suppresses endothelial cell apoptosis
S Brouard, LE Otterbein, J Anrather… - The Journal of …, 2000 - rupress.org
… One such gene is the stress responsive gene heme oxygenase 1 (HO-1). Heme oxygenases
are the rate-limiting enzymes in the catabolism of heme into biliverdin, free iron, and carbon …
are the rate-limiting enzymes in the catabolism of heme into biliverdin, free iron, and carbon …
Heme oxygenase-1 protects pancreatic β cells from apoptosis caused by various stimuli
E Tobiasch, L Günther, FH Bach - Journal of Investigative …, 2001 - journals.sagepub.com
… In addition, we show that HO-1 suppresses β-cell apoptosis through a mechanism that is …
an antiapoptotic molecule that can suppress β-cell apoptosis. We show that the mechanism of …
an antiapoptotic molecule that can suppress β-cell apoptosis. We show that the mechanism of …
Heme-induced heme oxygenase-1 (HO-1) in human monocytes inhibits apoptosis despite caspase-3 up-regulation
D Lang, S Reuter, T Buzescu, C August… - International …, 2005 - academic.oup.com
… Monocyte activation, apoptosis and differentiation are hallmarks of most inflammatory … We
studied the effects of heme oxygenase-1 (HO-1) induced by its substrate hemin on apoptosis, …
studied the effects of heme oxygenase-1 (HO-1) induced by its substrate hemin on apoptosis, …
Heme oxygenase-1, a critical arbitrator of cell death pathways in lung injury and disease
D Morse, L Lin, AMK Choi, SW Ryter - Free Radical Biology and Medicine, 2009 - Elsevier
… We found that CSE activated the extrinsic apoptotic pathway in human epithelial cells (Beas-2B)
and primary human lung fibroblasts. CSE induced assimilation of the Fas-dependent …
and primary human lung fibroblasts. CSE induced assimilation of the Fas-dependent …
Different faces of the heme-heme oxygenase system in inflammation
FA Wagener, HD Volk, D Willis, NG Abraham… - Pharmacological …, 2003 - ASPET
… , the biosynthesis and the significance of heme and heme oxygenase is presented in view
of … In addition, the heme-HO system is discussed in relation to apoptosis and transplantation …
of … In addition, the heme-HO system is discussed in relation to apoptosis and transplantation …
Heme oxygenase-1 inhibits apoptosis in Caco-2 cells via activation of Akt pathway
J Busserolles, J Megías, MC Terencio… - … of biochemistry & cell …, 2006 - Elsevier
… Protection against apoptosis in cells treated with cobalt … heme oxygenase-1 small interfering
RNA. This study shows an antiapoptotic effect of heme oxygenase-1 in colon cancer cells …
RNA. This study shows an antiapoptotic effect of heme oxygenase-1 in colon cancer cells …
Heme oxygenase-1: unleashing the protective properties of heme
LE Otterbein, MP Soares, K Yamashita, FH Bach - Trends in immunology, 2003 - cell.com
… Carbon monoxide generated by heme oxygenase 1 suppresses endothelial cell apoptosis.
… ], the heme oxygenases are the only means by which a cell can catabolize heme. As such, …
… ], the heme oxygenases are the only means by which a cell can catabolize heme. As such, …
Heme oxygenase-1 contributes to an alternative macrophage activation profile induced by apoptotic cell supernatants
N Weis, A Weigert, A von Knethen… - … biology of the cell, 2009 - Am Soc Cell Biol
… Apoptotic cells (AC) are rapidly engulfed by professional phagocytes such as macrophages
… Here, we demonstrate a biphasic up-regulation of heme oxygenase-1 (HO-1), a protein that …
… Here, we demonstrate a biphasic up-regulation of heme oxygenase-1 (HO-1), a protein that …
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