… to the molecular components that activate apoptosis and the relevance of these to a variety
… for novel therapies based on our understanding of them. An understanding of the role of cell …

… on the regulation of apoptosis of cells within the vasculature, concentrating on the relevance
of apoptosis to plaque progression and clinical consequences of vascular cell apoptosis. …

… -induced immune cell apoptosis, including the role of innate and adaptive immune cells in
the … metabolic stage, and the clinical implications and potential therapeutic interventions. …

… regulators of cellular apoptosis. We also highlight the evidence of neuronal apoptotic death
in … evidence of potential therapeutic agents that could modify the apoptotic pathway in the …

… result of antibody-induced monocytes 42 and T cell apoptosis in the gut. … apoptosis of T
cells, suggesting that infliximab might be effective in Crohn’s disease because of its pro-apoptotic …

… In the field of death ligands and receptors, inducing cancer cell apoptosis via local or
systemic application of Apo2L/TRAIL is one of the most promising strategies. The growth of …

… -induced apoptosis. An … apoptosis found in many cell types, the apoptotic pathway in
cardiomyocytes is somewhat unconventional since in vivo experimental data reveal that apoptosis …

… Finally, because the topic of this review is apoptosis and phagocytic clearance of apoptotic
cells, the section on therapy below is focused on these processes. However, strategies to …

… cell death from necrosis. Extrinsic apoptotic cell death is receptor-linked and initiates
apoptosis by … Intrinsic apoptotic cell death is mediated by the release of cytochrome c from …

… with apoptotic cells and proceed their clearance. Another molecule shown to be involved
in the recognition of clearance of apoptotic cells is C1q, which binds to apoptotic cells and …