… A number of different methods have been developed to detect and measure DNA adducts in
… agents on DNA adduct level. AMS has been used to measure DNA adducts in human tissue …

… in the identification of DNA adducts. A vivid history of … cell carcinomas lower frequencies
ofp53 mutations were noted, but dipyrimidine sites were overwhelming in basal cell carcinomas …

… Data suggest that no single adduct isresponsible for the initiation of chemical … of all
promutagenic DNA adducts and the extent of cell replication for each population of cells exposed …

… Quantitation of DNA adducts in human tissues has been achieved with highly sensitive …
based on adduct radiolabeling, antisera specific for DNA adducts or modified DNA, and/or adduct …

… of DNA adducts by metabolically activated intermediates. Detecting the presence of DNA
adducts in … A large body of evidence demonstrates that DNA adducts are useful markers of …

… between oxidative DNA lesions and aromatic DNA adducts, six modified DNA bases 5-hydro…
dine and the total level of PAH-related DNA adducts were measured in cancerous and the …

… We identify that mutations linked to DNA adducts associated with tobacco smoke exposure
are … growth and increased susceptibility to mutations from tobacco carcinogen DNA adducts. …

… DNA adduct formation in the cell cycle is primarily dependent on cell cycle-related modulations
in the production of electrophilic ultimate carcinogens from inactive precursor compounds…

… 19, 20 In this study of squamous cell carcinoma of the head and neck, we provide further
supporting evidence that the BPDE-induced DNA adduct assay indeed has potential value as a …

… cell carcinoma of the … DNA adduct is a piece of DNA covalently bond to a chemical (safrole,
benzopyrenediol epoxide, acetaldehyde). This process could be the start of a cancerous cell. …