Human HIF‐3Α4 is a Dominant‐Negative regulator of HIF‐1 and is Down‐Regulated in renal cell carcinoma

MA Maynard, AJ Evans, T Hosomi, S Hara… - The FASEB …, 2005 - Wiley Online Library
… These results demonstrate an important dominant-negative regulation of HIF-1-mediated …
dominant-negative regulator of HIF-1 and is down-regulated in renal cell carcinoma. FASEB …

… negative regulation between S100A7/psoriasin and β-catenin signaling plays an important role in tumor progression of squamous cell carcinoma of oral cavity

G Zhou, TX Xie, M Zhao, SA Jasser, MN Younes… - Oncogene, 2008 - nature.com
… In this study, we have shown that the reciprocal negative regulation of S100A7 and β-catenin
signaling plays an important role in tumor progression of SCCOC. On the basis of our …

[HTML][HTML] Negative regulation of tumor-infiltrating NK cell in clear cell renal cell carcinoma patients through the exosomal pathway

Y Xia, Q Zhang, Q Zhen, Y Zhao, N Liu, T Li, Y Hao… - Oncotarget, 2017 - ncbi.nlm.nih.gov
… killer cells functions in clear cell renal cell carcinomacells in clear cell renal cell carcinoma
patients vs healthy controls. With an inhibitory phenotype, tumor-infiltrating natural killer cells

p21—negative regulator of the cell cycle

AL Gartel, MS Serfas, AL Tyner - Proceedings of the Society …, 1996 - journals.sagepub.com
… entry into S phase by inactivating Cdks or by inhibiting activity of proliferating cell nuclear
antigen (PCNA). In normal cells, p21 exists in quaternary complexes with cyclin, Cdk, and …

[HTML][HTML] T-Cadherin is an auxiliary negative regulator of EGFR pathway activity in cutaneous squamous cell carcinoma: impact on cell motility

E Kyriakakis, K Maslova, M Philippova, D Pfaff… - Journal of investigative …, 2012 - Elsevier
… This study has identified T-cad as a negative auxiliary regulator of EGFR pathway activation
in SCC, with consequences for functional responses of SCC to EGF. First, spheroid invasion …

Tumor invasion and metastasis: an imbalance of positive and negative regulation

LA Liotta, WG Stetler-Stevenson - Cancer research, 1991 - AACR
… , Cornil, I., Fernandez, B.,and Kerbel, RS Overexpression of normal and mutated forms of
C-Ha-Aaj induce orthotopic bladder invasion in a human transitional cell carcinoma. Proc. Nati. …

Leukemia inhibitory factor receptor suppresses the metastasis of clear cell renal cell carcinoma through negative regulation of the yes-associated protein

C Lei, S Lv, H Wang, C Liu, Q Zhai, S Wang… - DNA and Cell …, 2018 - liebertpub.com
The role of leukemia inhibitory factor receptor (LIFR), which is important in the signal transduction
of the interleukin-6 cytokine family, is still undefined in clear cell renal cell carcinoma (…

Negative regulation of the major histocompatibility class I gene in undifferentiated embryonal carcinoma cells.

JL Miyazaki, E Appella, K Ozato - Proceedings of the …, 1986 - National Acad Sciences
… CAT activity in differentiated F9 cells. These data suggest the presence of a negative cis-acting …
Further analysis revealed that the sequence conferring the negative regulation resides …

[PDF][PDF] Negative regulation of hepatocellular carcinoma cell growth by signal regulatory protein α1

HX Yan, HY Wang, R Zhang, L Chen, BA Li… - …, 2004 - Wiley Online Library
cells to TNF or cisplatin-induced cell death. In addition, SIRP 1-transfected Huh7 cells displayed
reduced cell migration and cell … In conclusion, a negative regulatory effect of SIRP 1 on …

PIK3IP1, a negative regulator of PI3K, suppresses the development of hepatocellular carcinoma

X He, Z Zhu, C Johnson, J Stoops, AE Eaker, W Bowen… - Cancer research, 2008 - AACR
cellular responses (1). We recently identified and characterized a new negative regulator of
… region sharing homology with the p85 regulatory subunit. When overexpressed in cultured …