… cell cultures of rat alveolar macrophages to characterize the ability of these cells to accumulate
… amiodarone and desethylamiodarone accumulate within the alveolar macrophages. This …

… In chase experiments the drugloaded cell cultures were incubated four times for 1 hr with
MEM containing 20 mM ammonium chloride and AM10 or DEA, respectively. Details have …

… by Caco-2 cells.In this study, to clarify the mechanism of high accumulation of DEA in the
lung, we investigated the mechanism of AMD or DEA accumulation in A549 cells, a human …

… The most commonly administered drug used in treatment and prophylaxis is amiodarone
which … The aim of this study is to document the cytotoxic effects of amiodarone on cell culture …

… To obtain the studied concentrations, amiodarone was dissolved in the cell culture media.
Then… Intracellular accumulation of reactive oxygen species can arise from toxic insults and can …

… of Amiodarone after acute and repeated exposure in two advanced rodent brain cell culture
models, consisting of both neurons and glial cells … possibly affecting Amiodarone in vitro …

… AM10 and DEA toxicity in cell cultures. Results from the present … accumulation suggesting
a stoichiometric relationship. (u-TOC was also effective in clearing previously accumulated …

… Cell culture supplements were … cells/CYP3A4 at 50 μM amiodarone, suggesting that the
mitochondrial defense mechanisms for ROS accumulation were sufficient at lower amiodarone …

… of each well was removed, the empty cell culture plate was washed twice with PBS before
… to describe the potential accumulation of AMI and MDEA in those cells (quantity Q bcell ). In …

… Cell viability was determined by trypan blue exclusion and was always greater than 80%. Cells
were seeded into cell culture … , revealing micro- and macrovesicular accumulation of fat in …