Role of host cell secretory machinery in Zika virus life cycle

G Sager, S Gabaglio, E Sztul, GA Belov - Viruses, 2018 - mdpi.com
virus co-circulates with Dengue viruses since cross-reactivity of Dengue and Zika virus
antibodies has been demonstrated in cell culture … against this emerging virus [15,16,17,18,19]. …

Zika virus infects human cortical neural progenitors and attenuates their growth

H Tang, C Hammack, SC Ogden, Z Wen, X Qian, Y Li… - Cell stem cell, 2016 - cell.com
… Shown are sample flow cytometry analyses of distributions of hNPCs (from the C1-2 line)
at different phases of the cell cycle 72 hr after ZIKV or mock infection. For the mixture sample, …

[HTML][HTML] Genome-wide integrative analysis of Zika-virus-infected neuronal stem cells reveals roles for microRNAs in cell cycle and stemness

JW Dang, SK Tiwari, Y Qin, TM Rana - Cell reports, 2019 - cell.com
Zika virus (ZIKV) infection is implicated in severe fetal developmental disorders, including
microcephaly. MicroRNAs (miRNAs) post-transcriptionally regulate numerous processes …

[HTML][HTML] Zika virus envelope protein induces G2/M cell cycle arrest and apoptosis via an intrinsic cell death signaling pathway in neuroendocrine PC12 cells

J Liu, Q Li, X Li, Z Qiu, A Li, W Liang… - … Journal of Biological …, 2018 - ncbi.nlm.nih.gov
… PC12 cells. Our results confirmed the effect of ZIKV Env protein in interfering with the cell
cycle suggesting a role in abnormal nervous system development. The cell cycle arrest and …

Zika virus infection induces DNA damage response in human neural progenitors that enhances viral replication

C Hammack, SC Ogden, JC Madden Jr… - Journal of …, 2019 - Am Soc Microbiol
cells (hNPCs) and leads to growth arrest of these cells, which … ZIKV, but not dengue virus,
disrupts the cell cycle of hNPCs by … ZIKV manipulates the cell cycle to benefit viral replication. …

Zika virus disrupts molecular fingerprinting of human neurospheres

PP Garcez, JM Nascimento, JM de Vasconcelos… - Scientific reports, 2017 - nature.com
… Interestingly, here we show that ZIKV alters cell cycle targets in progenitor cells, in parallel
to cell death induction. Our work provides insights into the molecular mechanisms behind …

Zika virus and the metabolism of neuronal cells

HA Rothan, S Fang, M Mahesh, SN Byrareddy - Molecular neurobiology, 2019 - Springer
… Unlike DENV, Zika virus infects mature neuronal cells that express AXL receptors causing
neurological disorders [41]. Importantly, neurons lack the glycolysis promoting enzyme 6-…

Zika virus

D Musso, DJ Gubler - Clinical microbiology reviews, 2016 - Am Soc Microbiol
Zika virus (ZIKV) is an arthropod-borne virus (arbovirus) in the genus Flavivirus and the
family Flaviviridae . ZIKV was first isolated from a nonhuman primate in 1947 and from …

Biology of Zika virus infection in human skin cells

R Hamel, O Dejarnac, S Wichit, P Ekchariyawat… - Journal of …, 2015 - Am Soc Microbiol
Zika virus (ZIKV) is an emerging arbovirus of the Flaviviridae family, which includes dengue,
West Nile, yellow fever, and Japanese encephalitis viruses… , and immature dendritic cells are …

Zika virus induced cellular remodelling

ED Rossignol, KN Peters, JH Connor… - Cellular …, 2017 - Wiley Online Library
Zika virus (ZIKV) has been associated with morbidities such … The spread of this positive-sense,
single-stranded RNA virus … of the virus replication cycle within mammalian cells, we use …