… molecules can lead to immunogenic cell death (ICD) of tumor cells, which release damage-…
(T cell)–mediated adaptive immune system can become activated. Activated T cells then …

… The maintenance of cellular homeostasis is fundamental for tissue integrity in multi… , namely
by TRADD which is also responsible for bridging TNF-R1 to TRAF2 and the IKK complex. …

… The early characterization of the fundamental processes involved in apoptotic cell death
has since led to a variety of more or less stringent definitions of apoptosis. The discovery of …

… -8, and thereby as a bridge between two critical organelles involved in apoptosis signaling.
… Regardless of the main execution pattern, death programs have at least two fundamental …

… Cell death is a fundamental physiological process in all living organisms. Its roles extend
from embryonic development, organ maintenance, and aging to the coordination of immune …

… cellular stress (intrinsic pathway with caspase 9). Recruitment and activation of the initiator
caspases is achieved by adapter molecules that bridge to death … There are two fundamental …

… protein Apaf-1, which consists of three fundamental units: a sensor for an apoptotic stimulus
(… In this model, each winged-helix domain from the NB-ARC region forms a bridge between …

Programmed cell death (apoptosis) is recognized, increasingly, as a contributing cause of
cardiac myocyte loss with ischemia/reperfusion injury, myocardial infarction, and long-…

… the cell death programme. Recently defined genetic connections between C. elegans cell
death … system as a model for cell death in mammalian cells, which, inevitably, is more complex. …

… to regulate fundamental cellular processes by inducing apoptosis or triggering inflammatory
cell death. … These adaptors bridge the initiator caspases, such as caspase-8 or -10, to form a …