… This review describes the functions and regulation of the FADD-caspase-8-cFLIP
complex in cell death and non-cell death pathways with a particular focus on caspase-8. …

… the involvement of caspase-8 in cell death and inflammation and highlight its role in innate
immune responses and in the relationship between different forms of cell death. Caspase-8 is …

… cell proliferation. Recent work has indicated that the requirement for caspase 8 in development
and immune cell … triggers an alternative form of cell death called programmed necrosis. …

… focus on caspase regulation of TRAIL-induced cell death, specifically caspase-8. Initiator …
Caspase-8 is the focal apical caspase for the TRAIL signaling pathway and this review will …

… Furthermore, Caspase-8 also plays a crucial pro-survival function by inhibiting an
alternative form of programmed cell death called necroptosis. Low expression levels of pro-Caspase-8 …

… In this study, loss of casp8 expression by virtue of siRNA mediated casp8 knockdown
resulted in RIP1-dependent cell death (see below), implicating this caspase as an inhibitor of …

… caspase-8 knockout mice and caspase8–defective mutant cell lines has convincingly indicated
that caspase-8 … The FADD/caspase-8 cell death pathway was initially identifi ed through …

… In this review, we discuss the emerging crosstalk between cell death and innate immune
cell inflammatory signalling, particularly focusing on novel non-apoptotic functions of caspase-8…

… by caspase-1 13 , were elevated in Casp8 C362A/C362A Mlkl −/− embryos, we tested
whether pyroptotic cell death driven by caspase-1 or caspase-11 contributed to the death of …

… Additional studies indicate that the enzymatic activity of caspase-8 is required for the … of
cell death 12,13 . To investigate the physiological role of the enzymatic activity of caspase-8, we …