Targeting cell death signalling in cancer: minimising 'Collateral damage'

JL Fox, M MacFarlane - British journal of cancer, 2016 - nature.com
… depend upon the induction of a form of cell death known as apoptosis. Evasion of apoptosis
is… cell death ligands of the TNF cytokine family that act via death receptors located on the cell

Collateral damage: necroptosis in the development of lung injury

H Faust, NS Mangalmurti - … of Physiology-Lung Cellular and …, 2020 - journals.physiology.org
… on nonapoptotic programmed cell death pathways such as … Necroptosis, a cell death
program involving the receptor … to lytic cell death with subsequent release of damage-associated …

Erythropoietin‐mediated tissue protection: reducing collateral damage from the primary injury response

M Brines, A Cerami - Journal of internal medicine, 2008 - Wiley Online Library
… Acutely, EPO prevents programmed cell death and reduces the development of secondary,
pro-inflammatory cytokine-induced injury. Within a longer time frame, EPO provides trophic …

Cell death: a review of the major forms of apoptosis, necrosis and autophagy

MS D'arcy - Cell biology international, 2019 - Wiley Online Library
… programmed cell death) or necrosis (uncontrolled cell death); … of cell death have been
discovered highlighting that a cell can … , reduces the risk of collateral damage to surrounding cells. …

Control of in vivo collateral damage generated by T cell immunity

G Thangavelu, RG Gill, L Boon, KK Ellestad… - The Journal of …, 2013 - journals.aai.org
cells while also minimizing collateral damage to adjacent noninfected tissues. The factors
limiting bystander cell … CD8 T cells do have the capacity to inflict adjacent tissue damage and …

CD8+ T cells and neuronal damage: direct and collateral mechanisms of cytotoxicity and impaired electrical excitability

N Melzer, SG Meuth, H Wiendl - The FASEB Journal, 2009 - Wiley Online Library
… electrical signaling and cell death of neurons as direct and collateral targets of CD8 + T …
recently reported to be associated with substantial collateral damage to neurons. In PML, latent …

Collateral damage: insights into bacterial mechanisms that predispose host cells to cancer

A Gagnaire, B Nadel, D Raoult, J Neefjes… - Nature Reviews …, 2017 - nature.com
… (if not decades) before transformed cells form a malignant metastasizing tumour. 'Hallmarks'
of cancer cells include a resistance to cell death signals, the evasion of growth suppressors, …

Apoptosis: an identical central or collateral mechanism in the development, function and death of neurons

G Mathé - Biomedicine & pharmacotherapy, 1997 - Elsevier
damage [10]. Hara [ll] has shown that Bax and its related protein Bcl-2 are essential for the
regulation of apoptotic cell death - an active cell-… and apop- totic cell death, the prevailing …

The DNA damage-induced cell death response: a roadmap to kill cancer cells

S Matt, TG Hofmann - Cellular and Molecular Life Sciences, 2016 - Springer
… For example, major collateral damage includes nephrotoxicity and neurotoxicity for platinum
anticancer drugs and cardiotoxicity for Doxorubicin/Adriamycin [9, 10]. To optimize cancer …

Evidence that ischemic cell death begins in the subendocardium independent of variations in collateral flow or wall tension.

JE Lowe, RG Cummings, DH Adams, EA Hull-Ryde - Circulation, 1983 - Am Heart Assoc
collateral flow or wall tension. In this study, 10 left ventricular globally ischemic slabs were
created that were free of wall tension and collateral … ischemia in vitro, cell death begins in the …