Synergistic cell death in FLT3-ITD positive acute myeloid leukemia by combined treatment with metformin and 6-benzylthioinosine

HS Sabnis, HL Bradley, S Tripathi, WM Yu, W Tse… - Leukemia research, 2016 - Elsevier
… In this study, we tested metformin in combination with 6-BT and found that the two drugs
can synergize to promote cell death in FLT3-ITD AML cell lines. This effect was marginally …

New combination strategies using programmed cell death 1/programmed cell death ligand 1 checkpoint inhibitors as a backbone

S Hu-Lieskovan, A Ribas - The Cancer Journal, 2017 - journals.lww.com
… which led to the approval of this combination therapy in treating advanced melanoma in 2015.
It … combination versus ipilimumab and nivolumab versus ipilimumab, but not combination

The combination of ADI-PEG20 and TRAIL effectively increases cell death in melanoma cell lines

M You, N Savaraj, M Wangpaichitr, C Wu… - Biochemical and …, 2010 - Elsevier
… To further confirm that caspase activation is important in cell death caused by the combination
treatment, we used caspase-3 inhibitor to determine whether reversal of cell death could …

Mechanism of cell death induction by nitroxide and hyperthermia

QL Zhao, Y Fujiwara, T Kondo - Free Radical Biology and Medicine, 2006 - Elsevier
… The combined treatment induced 97% zVAD-resistant low-… Here we report for the first time
that when combined with heat … cell death, which results in the irreparable inhibition of cell

Combined treatment with SAHA, bortezomib, and clarithromycin for concomitant targeting of aggresome formation and intracellular proteolytic pathways enhances ER …

S Komatsu, S Moriya, XF Che, T Yokoyama… - Biochemical and …, 2013 - Elsevier
… We demonstrate here that combined treatment with SAHA, CAM, and BZ exhibited
pronounced ER-stress-mediated breast cancer cell death, providing a novel strategy of ER-stress …

JNK/p53 mediated cell death response in K562 exposed to etoposide‐ionizing radiation combined treatment

N Sabatini, VD Giacomo, M Rapino… - Journal of cellular …, 2005 - Wiley Online Library
… pathways in cell death response of K562 cells to etoposide and IR treatment. Our results let
us suppose that the induction of cell death, already evident in 15 Gy exposed cells, mainly in …

Combined PARP and ATR inhibition potentiates genome instability and cell death in ATM-deficient cancer cells

RL Lloyd, PWG Wijnhoven, A Ramos-Montoya… - Oncogene, 2020 - nature.com
… Here, we demonstrate in several ATM-deficient cell lines that the olaparib and AZD6738
combination induces cell death within 1–2 cell divisions, suggesting that combined treatment

The combination of irreversible EGFR TKI s and SAHA induces apoptosis and autophagy‐mediated cell death to overcome acquired resistance in EGFR T 790 M …

TG Lee, EH Jeong, SY Kim, HR Kim… - International journal of …, 2015 - Wiley Online Library
… different from apoptosis.38, 39 We next tried to determine whether the autophagic cell
death was induced by combined treatment of BIBW2992 or WZ4002 and SAHA in PC-9G …

Combination of cisplatin and irradiation induces immunogenic cell death and potentiates postirradiation anti–PD-1 treatment efficacy in urothelial carcinoma

H Fukushima, S Yoshida, T Kijima, Y Nakamura… - International Journal of …, 2021 - mdpi.com
… , a combination of cisplatin and irradiation, could improve the efficacy of postirradiation
anti–programmed cell death 1 (PD-1) treatment … models by inoculating MB49 cells sc in C57BL/6J …

Mechanisms in photodynamic therapy: part two—cellular signaling, cell metabolism and modes of cell death

AP Castano, TN Demidova, MR Hamblin - … and photodynamic therapy, 2005 - Elsevier
… This mechanistic research is expected to lead to optimization of PDT as a tumor treatment,
and to rational selection of combination therapies that include PDT as a component. …