… Despite the extraordinary developments in understanding the immunopathology of sepsis,
therapeutic advances have been painfully slow. However, in the past 12 months several …

… the role immune cell apoptosis plays in the development of sepsis, with an aim … cell death
during sepsis. We will also briefly discuss parenchymal cell apoptosis in different organs, cells …

… , and can transduce signals resulting in cell death 33. NF-κB-… does not result in widespread
cell death. In situations where … While the molecular immunopathology of severe sepsis …

… of IFNγ and TNF than do splenic T cells obtained from patients who died from a … cells
harvested from patients who died from sepsis have increased expression of programmed cell death …

… septic shock with increasing age [3]. The major contributing factors that account for the excess
risk of infection and severe sepsis … precipitate an excess risk of death from septic shock. …

… is characterized by among others the release of pro-inflammatory mediators, activation of
the complement and the coagulation systems and the release of alarmins by necrotic cell death…

… necessity of unraveling sepsis’ immunopathogenesis in a broad … cells are activated during
the acute phase of sepsis, and … By what mechanism does GM-CSF produced by IRA B cells …

… Additionally, these cells, via direct contact, were … cell death/dysfunction (another common
feature of the septic animal/patient) as well as altering the migrational functionality of the cell (a …

… of monocytes, dendritic cells also undergo increased apoptosis in sepsis, further impairing …
1 programmed cell death (PCD), is responsible for the majority of immune cell death in sepsis …

… of immune cells differs under diverse apoptotic signals during sepsis. Cellular death through
… and organ failure during sepsis, with apoptotic immune cells contributing to secondary …