[HTML][HTML] IgM phosphorylcholine antibodies inhibit cell death and constitute a strong protection marker for atherosclerosis development, particularly in combination with …

R Fiskesund, J Su, I Bulatovic, M Vikström… - Results in …, 2012 - Elsevier
… The population of anti-PC antibodies in serum is generally … I antibodies binds both
phosphorycholine (PC) and p-nitrophenyl phosphorylcholine (NPPC) whereas Group II antibodies

Antibodies against phosphorylcholine and protection against atherosclerosis, cardiovascular disease and chronic inflammation

J Frostegård - Expert Review of Clinical Immunology, 2022 - Taylor & Francis
… endothelial cells and macrophages, activation of T cells, promotion of cells death and
being taken up by macrophages and other cell types which develop into inert foam cells[Citation1]. …

The autoreactivity of anti-phosphorylcholine antibodies for atherosclerosis-associated neo-antigens and apoptotic cells

PX Shaw, CS Goodyear, MK Chang… - The Journal of …, 2003 - journals.aai.org
… , PCG1–14, and/or that the determinants recognized by these two types of Abs are differentially
generated, or revealed, in the cell membrane at distinct stages of programmed cell death. …

Antibodies against Phosphorylcholine—Implications for Chronic Inflammatory Diseases

J Frostegård - Metabolites, 2023 - mdpi.com
… These cells produce mainly proinflammatory cytokines. OxLDL can activate … cell types and
also causes cell death and is taken up by macrophages which develop into inert foam cells

Different subclasses and isotypes of antibodies against phosphorylcholine in haemodialysis patients: association with mortality

SK Samal, AR Qureshi, M Rahman… - Clinical & …, 2020 - academic.oup.com
death [3]. OxLDL is proinflammatory and immune stimulatory, and could also be a cause of
cell death … we have previously reported that specifically, phosphorylcholine (PC), an important …

[PDF][PDF] Immunoglobulin G1 antibodies against phosphorylcholine are associated with protection in systemic lupus erythematosus and atherosclerosis: Potential …

D Thiagarajan, R Fiskesund, A Frostegård… - ACR open …, 2020 - Wiley Online Library
Objective Immunoglobulin M antibodies against phosphorylcholine (anti‐ PC s) may be
protective in atherosclerosis, cardiovascular disease ( CVD ), and systemic lupus erythematosus …

High anti-phosphorylcholine antibody levels and mortality associated with pneumonia

G Nordenstam, B Andersson, D Brile… - … journal of infectious …, 1990 - Taylor & Francis
… and since anti-polysaccharide antibodies are highly protective against most … of antibodies
to phosphorylcholine. The relationship between the levels of antibodies to phosphorylcholine

Phosphorylcholine-targeting immunization reduces atherosclerosis

G Caligiuri, J Khallou-Laschet, M Vandaele… - Journal of the American …, 2007 - jacc.org
… from atherosclerotic lesions of phosphorylcholine (PC)-immunized … anti-CD3 antibody, B
cells with an anti-CD19 antibody, MHC II + cells with an anti–IA b antibody, and T15 antibodies

Antibodies against native and oxidized cardiolipin and phosphatidylserine and phosphorylcholine in atherosclerosis development

AG Frostegård, J Su, X Hua, M Vikström, U de Faire… - PLoS …, 2014 - journals.plos.org
… that natural IgM antibodies against phosphorylcholine (anti-PC) … that low levels of such
antibodies predispose to CVD [2]. … increased, anti-phospholipid antibodies against cardiolipin and …

PD-L2 regulates B-1 cell antibody production against phosphorylcholine through an IL-5–dependent mechanism

JT McKay, MA Haro, CA Daly, RD Yammani… - The Journal of …, 2017 - journals.aai.org
… In this study, we demonstrate that programmed cell death 1 ligand 2 (PD-L2) regulates the
production of natural Abs against phosphorylcholine (PC). Naive PD-L2–deficient (PD-L2 −/− …