… In this study, we demonstrate that programmed cell death 1 ligand 2 (PD-L2) regulates the
production of natural Abs against phosphorylcholine (PC). Naive PD-L2–deficient (PD-L2 −/− …

… of T regulatory cells, inhibition of cell death, and increased clearance of dead cells. Methods:
… , leads to low levels of the antibodies described and a lack of ability to prevent autoimmune …

… Since accumulation of dead cells is a major feature of atherosclerosis, IgM anti-PC-induced
inhibition of cell death caused by an important inflammatory phospholipid, …

… are often described as being T-cell independent [10]. We here report that these antibodies
are, surprisingly, T-cell dependent, increase phagocytosis of apoptotic cells and are striking …

… Natural antibodies specific for phosphorylcholine (anti-PC) have been implicated as
protective factors in atherosclerosis. We herein determined the relationship between IgM anti-PC …

… Phosphorylcholine (PC) may play an important role in the atherogenic and pro-inflammatory …
We recently demonstrated that low levels of IgM antibodies against PC (anti-PC) are …

… inhibit cell death caused by major OxLDL components (20). Further, anti-PC is anti-inflammatory,
inhibiting the effects of inflammatory phospholipids (8), which increases clearance of …

… Anti-phosphocholine (PC) antibody mediated protection against many strains of Streptococcus
pneumoniae, and hybridoma anti-PC antibodies … PC accessible to antibody. Furthermore, …

… antibody TI5 inhibits uptake of oxLDL in macrophages and thus development of foam cells,
… from pooled human IG and that these antibodies inhibit PAF-induced endothelial activation, …

… than IgM antibody. This observation fits with our earlier findings that IgG anti-PC antibody is
… that anti-PC antibody initially is not as efficient as anticapsular antibody at inducing blood …