The role of IgM antibodies in the recognition and clearance of apoptotic cells

YF Peng, R Kowalewski, SJ Kim, KB Elkon - Molecular immunology, 2005 - Elsevier
… Programmed cell death (apoptosis) is acknowledged to play critical role in both … One of
the membrane phospholipid substrates of iPLA 2 is phosphorylcholine (PC). Activated iPLA 2 …

A novel phosphocholine‐mimetic inhibits a pro‐inflammatory conformational change in C‐reactive protein

J Zeller, KS Cheung Tung Shing, TL Nero… - EMBO Molecular …, 2023 - embopress.org
… to activated/damaged cell membranes via exposed phosphocholine lipid head … of
phosphocholine as a template. X‐ray crystallography revealed specific binding to the …

Intrathecal treatment with the anti-phosphorylcholine monoclonal antibody TEPC-15 decreases neuronal damage in experimental pneumococcal meningitis

J Gerber, S Redlich, S Ribes, SC Tauber, H Schmidt… - Chemotherapy, 2012 - karger.com
… units conjugated to phosphorylcholine. LTA cause profound … Since bacterial cell wall
components induce microglial … of the anti-phosphorylcholine monoclonal mouse IgA antibody

Intranasal immunization with protein-linked phosphorylcholine protects mice against a lethal intranasal challenge with Streptococcus pneumoniae

S Trolle, E Chachaty, N Kassis-Chikhani, C Wang… - Vaccine, 2000 - Elsevier
… Our results for mice immunized ip or sc demonstrated that secretory antibodies were not
essential to prevent death after nasal inoculation of an invasive S. pneumoniae strain. …

S‐1‐Ophosphocholine‐2‐N‐acetyl‐octadecane induces apoptosis in T cells: Involvement of receptor activation and the intrinsic apoptotic pathway

C Oberle, U Massing, HF Krug - Signal Transduction, 2003 - Wiley Online Library
… into tumor cells and induces cell death via intracellular activation of the cell death receptor …
were selected after several rounds of treatment with CD95-antibody in order to obtain a cell

Antiphosphocholine antibodies found in normal mouse serum are protective against intravenous infection with type 3 streptococcus pneumoniae.

DE Briles, M Nahm, K Schroer, J Davie… - The Journal of …, 1981 - rupress.org
… (1, 2), the protective properties of antibodies to other pneumococcal constituents have been
antibodies binding with the phosphocholine (PC)1 determinant of the pneumococcal cell

[PDF][PDF] IgM antibodies against malondialdehyde and phosphorylcholine in different systemic rheumatic diseases.

D Thiagarajan, N Oparina, S Lundström… - ANNALS OF THE …, 2019 - academia.edu
… IgM phosphorylcholine antibodies inhibit cell death and constitute a strong protection
marker for atherosclerosis development, particularly in combination with other auto-antibodies

Immune response to Trichinella epitopes: the antiphosphorylcholine plaque-forming cell response during the biological cycle

FM Ubeira, J Leiro, MT Santamarina, TG Villa… - Parasitology, 1987 - cambridge.org
… -PC antibody levels during natural infection by Trichinella spiralis. This article reports a study
in which spleen cells … Such is the case of the epitope phosphorylcholine (PC), an immuno…

[HTML][HTML] A non-catalytic role of choline kinase alpha is important in promoting cancer cell survival

SC Falcon, CS Hudson, Y Huang, M Mortimore… - Oncogenesis, 2013 - nature.com
… The enzyme catalyses the formation of phosphocholine (… in HeLa cells resulted in significant
cell death through apoptosis. … (PI) and a fluorescently-labelled antibody targeting the 89 kDa …

[HTML][HTML] Protection against oxidative stress-induced cell death by intracellular platelet-activating factor-acetylhydrolase II

A Matsuzawa, K Hattori, J Aoki, H Arai… - Journal of Biological …, 1997 - ASBMB
… 1-O-hexadecyl-2-[ 3 H-acetyl]-sn-glycero-3-phosphocholine … goat anti-mouse Ig polyclonal
antibodies were obtained from … treatment of MDBK cells with the anti-PAF-AH(II) antibody. It …