… Apoptosis is frequently dysregulated in human cancers, and recent advancements in our
understanding of the regulation of programmed cell death pathways has led to the …

… , DcR2 or OPG, as these receptors do not induce cell death. Binding of death receptor
agonists to the receptors DR4 and/or DR5 results in DISC (death-inducing signaling complex) …

… of death receptor-ligand systems and how this inspired new concepts in cancer therapy and
our current understanding of the interplay between cell death … of TRAIL receptor agonists in …

… Targeting the death receptor pathway of apoptosis represents … therapeutics, since death
receptors on the cell surface are … of death receptors enables stimulation of intrinsic cell death …

… This simple mechanism explains much of the cell death that is induced by death receptors. …
for the development of therapeutics based on death receptor agonists and antagonists. …

… In colon cancer cells, LXR agonists induce pyroptotic cell death through the predominant …
cell death induced by LXR agonists in colon cancer cells could elicit immunogenic cell death …

… that TLR agonists induced a robust response in HNSCCs, characterized by generation of
inflammation and cell death. A similar response was not seen in normal epithelial cells. Thus, …

… death receptor agonists in view of what is known about the molecular mechanisms of how
TRAIL death receptors trigger intracellular cell death … TRAIL death receptor agonists and their …

The death receptors Fas and DR5 are known to be expressed not only in immune cells but
also in various tumor cells. The aim of the present study was to determine whether X …

… In this report, we have identified a novel mechanism for vanilloid receptor-mediated cancer
cell death, which targets mitochondrial function rather than the cell-surface vanilloid receptor. …