Death receptor agonists as a targeted therapy for cancer
J Wiezorek, P Holland, J Graves - Clinical cancer research, 2010 - AACR
… Apoptosis is frequently dysregulated in human cancers, and recent advancements in our
understanding of the regulation of programmed cell death pathways has led to the …
understanding of the regulation of programmed cell death pathways has led to the …
Death receptor agonist therapies for cancer, which is the right TRAIL?
PM Holland - Cytokine & growth factor reviews, 2014 - Elsevier
… , DcR2 or OPG, as these receptors do not induce cell death. Binding of death receptor
agonists to the receptors DR4 and/or DR5 results in DISC (death-inducing signaling complex) …
agonists to the receptors DR4 and/or DR5 results in DISC (death-inducing signaling complex) …
Death receptor–ligand systems in cancer, cell death, and inflammation
H Walczak - Cold Spring Harbor perspectives in biology, 2013 - cshperspectives.cshlp.org
… of death receptor-ligand systems and how this inspired new concepts in cancer therapy and
our current understanding of the interplay between cell death … of TRAIL receptor agonists in …
our current understanding of the interplay between cell death … of TRAIL receptor agonists in …
Safety and tolerability of TRAIL receptor agonists in cancer treatment
S Fulda - European journal of clinical pharmacology, 2015 - Springer
… Targeting the death receptor pathway of apoptosis represents … therapeutics, since death
receptors on the cell surface are … of death receptors enables stimulation of intrinsic cell death …
receptors on the cell surface are … of death receptors enables stimulation of intrinsic cell death …
Death receptor-induced cell killing
A Thorburn - Cellular signalling, 2004 - Elsevier
… This simple mechanism explains much of the cell death that is induced by death receptors. …
for the development of therapeutics based on death receptor agonists and antagonists. …
for the development of therapeutics based on death receptor agonists and antagonists. …
Treatment of colon cancer with liver X receptor agonists induces immunogenic cell death
Q Wang, M Ren, F Feng, K Chen… - Molecular …, 2018 - Wiley Online Library
… In colon cancer cells, LXR agonists induce pyroptotic cell death through the predominant …
cell death induced by LXR agonists in colon cancer cells could elicit immunogenic cell death …
cell death induced by LXR agonists in colon cancer cells could elicit immunogenic cell death …
Toll‐like receptor agonists induce inflammation and cell death in a model of head and neck squamous cell carcinomas
C Rydberg, A Månsson, R Uddman, K Riesbeck… - …, 2009 - Wiley Online Library
… that TLR agonists induced a robust response in HNSCCs, characterized by generation of
inflammation and cell death. A similar response was not seen in normal epithelial cells. Thus, …
inflammation and cell death. A similar response was not seen in normal epithelial cells. Thus, …
Molecular mode of action of TRAIL receptor agonists—Common principles and their translational exploitation
H Wajant - Cancers, 2019 - mdpi.com
… death receptor agonists in view of what is known about the molecular mechanisms of how
TRAIL death receptors trigger intracellular cell death … TRAIL death receptor agonists and their …
TRAIL death receptors trigger intracellular cell death … TRAIL death receptor agonists and their …
Enhanced induction of apoptosis by combined treatment of human carcinoma cells with X rays and death receptor agonists
T Hamasu, O Inanami, T Asanuma… - Journal of radiation …, 2005 - ieeexplore.ieee.org
The death receptors Fas and DR5 are known to be expressed not only in immune cells but
also in various tumor cells. The aim of the present study was to determine whether X …
also in various tumor cells. The aim of the present study was to determine whether X …
Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death
A Athanasiou, PA Smith, S Vakilpour… - Biochemical and …, 2007 - Elsevier
… In this report, we have identified a novel mechanism for vanilloid receptor-mediated cancer
cell death, which targets mitochondrial function rather than the cell-surface vanilloid receptor. …
cell death, which targets mitochondrial function rather than the cell-surface vanilloid receptor. …
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