… MYC enhancer controlled by NOTCH1 that is targeted by recurrent chromosomal duplications
in human T cell … NOTCH MYC enhancer, is located within a broad super-enhancer region +…

… both in normal physiological development and in MYC-driven cancer … cells while sparing
normal cells. Here we review the full enhancer landscape of MYC (Figure 1), or the MYC ‘…

… MYC enhancers that are activated in tumor cells. However, the role of this region in normal
development … kb deletion of the entire MYC upstream super-enhancer region in mice results …

… MYC is a major effector of NOTCH1 oncogenic programs in T-ALL. Here, we show a major
role for GATA3-mediated enhancer nucleosome eviction as a driver of MYC … MYC enhancer …

… e, Early B cell development in homozygous Myc Δ15–17/Δ15–17 and Myc ΔD/Δ15–17 mice
is shown as fraction of B220 + cells. f, Myc mRNA expression during B cell development in …

… Myc expression and to induce T-ALL and T-cell development (9), … Myc that is critical for
NTC-dependent Myc transcription. … Notch regulates Myc in both human and murine T-ALL cells. In …

… enhancers that control Myc expression in the developing face. … cell (NCC) enhancers 20 ,
showed lower expression levels. TFAP2A also interacts both genetically and directly with MYC …

… heavy-chain enhancer (E>) exhibit perturbed B-lymphocyte development and succumb to
B … enhancer has affected myc expression, we analyzed the structure and abundance of myc …

… enhancer-docking site in tumor cells reduces CTCF binding, super-enhancer interaction,
MYC gene expression, and cell … to DNA methylation, and this enhancer-docking site, which is …

… these cells are dependent on MYC expression for cell growth … During development, PSNS
cells derived from the embryonic … , dβh:MYC and dβh:MYCN zebrafish lines both develop …