… affinity antigens we were able to discern distinct influences of antigen affinity and antigen
dose on Th cell differentiation. … correlation between antigen affinity and Th1 differentiation that …

… these cases, antigen affinity may regulate entry into the early plasma cell compartment. Data
… importance of antigen affinity in the differentiation of plasma cells from GC B-cell precursors. …

… naïve B cell could also be influenced by BCR affinity for antigen. … B cells to high-affinity (HEL)
or medium-affinity (DEL) antigens to … APC-specific B cells (Fig. 4, A and B), which like MD4 …

… To investigate the effect of TCR affinity on SLEC differentiation in vivo, we examined the
expression of IL-7Ra and killer cell lectin-like receptor G1 (KLRG1) by flow cytometry. At the …

… Extrafollicular plasma cell differentiation is also … cell differentiation by initial antigen affinity
is indicative of a pivotal role for the BCR and its interaction with antigen in determining cell fate …

… and, moreover, total signal strength (from complement receptors, CD40 and probably
others) to the naïve B cell is a determinant that controls the B-cell differentiation pathway and …

… To examine how B cell receptor affinity affects clonal selection … with antibodies that showed
a 40-fold difference in affinity for … These cells differentiated into short-lived plasmacytes, as …

… Nevertheless, a clear picture of how early TD B cell differentiation is regulated awaits a
detailed analysis of the phenotypic and migrational changes that occur during this time. …

… but against low affinity and potentially self-reactive B cells … and how antigen affinity directs
the fate of each GC B cell via their … antigen affinity drives the plasma cell differentiation of high-…

… which low-affinity clonotypes … affinity threshold for memory CD4 T cell differentiation following
vaccination and suggests a role for nonapoptotic cell death in the regulation of CD4 T cell …