… affinity antibody responses. This can be attributed to the complexity of B cell differentiation
and affinity … , which makes these highly specialized cells susceptible to rapid apoptosis ex vivo…

… Germinal center B cells are thought to randomly diversify their Ig genes by a process of …
affinity variants are selectively preserved as memory cells for response to secondary antigenic …

… and human T cells on antigen-expressing feeder cells to develop higher-affinity TCRs. The
… In vitro differentiation of progenitors transduced with a known Tcra gene in the presence of …

… affinity B cells, only high affinity B cells responded to T cell–independent antigen and only
high affinity B cells accumulated in GCs after immunization with a T cell–dependent antigen. …

… immune response, to select those cells of highest antigen-binding affinity from a proliferating
immune … changing population of lymphoid cells from which plasma cells differentiate. As the …

… B-cell to plasma cell differentiation during the germinal center reaction has been shown. To
investigate if antigen affinity-based Tfh cell … model that integrates cellular interactions with a …

… So are virtually all the other innumerable antibodies used as … also affinity-matured antibodies.
Here, we wish to describe some molecular and cellular mechanisms that underlie affinity …

… and demonstrated that the binding of T cell activation-restricted mAb is not dependent on
de novo T cell epitope expression, but on mAb affinity and antigen density and/or clustering. …

… indicates that individual cells within the population differentiate in very different ways after
exposure to the antigen. We focus here on studies of CD4 + T cells and review evidence …

… of TCR affinity on differentiation and T cell/DC … T cells with differing TCR affinities for the
same p:MHCII ligand (20). We found that Th cells with low-, medium-, or high-affinity TCR T cells …