… T cell therapies, the impact of the affinity of the αβ TCR for the pepMHC cancer antigen on
… We discuss the advantages of higher-affinity TCRs in mediating potent activity of CD4 T cells…

… system, but the process of maintaining affinity diversity is unclear. We further … affinity T cells
and, therefore, highlight the important contribution of low-affinity T cells and a broad affinity …

… on affinity maturation of B cells. Competition from epitope-specific antibodies produced …
is essential for transport and deposition of antigen onto follicular dendritic cells (FDCs). It also …

… IgE or of several antibodies directed to the high affinity IgE receptor (… antibodies did inhibit
mAb AD1 binding as intact molecules but not as Fab fragments. Therefore, the sites on the cell …

… We thus propose that B cells may do mechanical work to drive their own evolution. To test
… of antigen extraction to a minimal model of affinity maturation, simulate ensembles of cell …

… in cell differentiation were controlled by binding of specific integrins to adsorbed FN.
Function-perturbing antibodies against the central cell … Furthermore, blocking antibodies against β …

… - and low-affinity B cells were equally able to respond to antigen in the absence … affinity
maturation during T cell–dependent antibody responses 38,39 . Antibodies elicited early in T cell–…

… of cell surface phenotypes, tumors of B cell origin were divided into three major subgroups,
which corresponded to the level of differentiation of the malignant tumor cell: pre-B cell … -B cell …

… -cell lineage. Our results establish a direct link between the affinity of the T-cell receptor for
self-antigens … also carefully tuned for proper iNKT cell differentiation and subsequent function. …

… responses, such as germinal center (GC) formation and the generation of high-affinity
long-lived plasma cells and memory cells, are dependent on help provided by CD4 + T …