… responses, such as germinal center (GC) formation and the generation of high-affinity
long-lived plasma cells and memory cells, are dependent on help provided by CD4 + T …

… in CD8 + T cell differentiation of effector and memory cells (3). Although Ag affinity has
been … to make separate contributions to T cell activation (17–20). Furthermore, whereas low-…

… antigen dose on the generation of Thl or Th2 cells was examined under rigidly defined
conditions. To ehminate the affinity … role of antigen dose and 16A hi CD4 + T cell differentiation, 9 …

… into cytokine-secreting effector Thl and Th2 cells is influenced by several factors. We … the
affinity of antigen for TCR and antigen dose can influence the differentiation of Thl and Th2 cells…

… affinity recombinant single-chain Ab with the Ag-specific MHC-restricted specificity of T cells
… The isolated Ab binds with high affinity, but TCR-like specificity to the recombinant gp100-…

… In light of our findings and along with recent works that describe high-affinity and high
antigen density attenuation of T-cell responses, these binding properties and their combination …

… thresholds for antigen activation (31, 54). We found that in … antigen affinity of B cells, activation
by antigen binding to the BCR is controlled by an inherent affinity threshold of the B cells. …

… Our investigation of AAM focused on antigen-specific GCB-cell differentiation and selection,
given the reports of active SHM in these models and autoantibodies (6, 21, 51–53). The (4-…

… antigenic peptides and stimulateT cells of the appropriate specificity when bound to a plate
(6). We have approached the question of TCR affinity … We conclude that the affinity of an indi…

… receptor expressed on both B cells and DCs, the TLR … affinity maturation and Ab responses
that were partially T cell independent, as Ag-specific IgGs were generated in CD40- and T cell…