… cal features of the disease, but considerable ignorance still surrounds its natural history
and determinants of its clinical severity. That ignorance is highlighted when clinical decisions …

Sickle cell disease (SCD) is a monogenic, yet highly phenotypically variable disease with
multisystem pathology. This manuscript provides an overview of many of the known …

… Biochemical and Clinical Aspects of Hemoglobin Abnormalities. New York: … clinical severity
of sickle cell disease: Epidemiologic aspects. In Caughey WS, ed. Biochemical and Clinical …

… follows a more severe clinical course in Africa than for the rest of the world and that infectious
diseases have a role in causing this increased severity of sickle-cell disease. More work is …

The relationship of the clinical features of homozygous sickle cell disease in the first two years
of life to the level of fetal hemoglobin at age 6 months was investigated. Mean HgbF levels …

… , but rarely among children with chronic disease. The purpose of this study … clinical severity,
family stressors, and mental health symptoms in children with homozygous sickle cell disease…

… clinical vasoocclusion [47,48]. As blood leucocyte counts correlate with clinical severity in
sickle cell disease, … cell vasoocclusion may also give rise to potential parameters for monitoring …

… Sickle cell disease (SCD) is one of the commonest severe inherited disorders in the world.
There are no accurate figures on how many people in the world are affected, although based …

… + -thalassemia are generally considered less severe. There are multiple compound … clinical
severity. Even within individual genotypes, there can be a broad range of disease severity. …

… A progressive vasculopathy related to hemolytic severity develops in some patients with
sickle cell disease 24 , 25 and is characterized by systemic hypertension, Doppler-…