Kinetics and mechanism of deoxyhemoglobin S gelation: a new approach to understanding sickle cell disease
J Hofrichter, PD Ross… - Proceedings of the …, 1974 - National Acad Sciences
… factors play in sickle cell disease. The rate of … gelation delay time to small changes in
physiological parameters points to the delay time as an extremely important variable in the disease. …
physiological parameters points to the delay time as an extremely important variable in the disease. …
Requirements for therapeutic inhibition of sickle haemoglobin gelation
HR Sunshine, J Hofrichter, WA Eaton - Nature, 1978 - nature.com
… the delay time seem to be associated with increased clinical severity of sickle cell disease". …
in which a decrease in the delay time of intracellular gelation, relative to the capillary transit …
in which a decrease in the delay time of intracellular gelation, relative to the capillary transit …
Iron in sickle cell disease: a review why less is better
PR Koduri - American journal of hematology, 2003 - Wiley Online Library
… after a significant time delay (delay time of gelation, Dt). The delay time of gelation is inversely
… The prolongation of Dt in excess of the capillary transit time may delay hemoglobin S …
… The prolongation of Dt in excess of the capillary transit time may delay hemoglobin S …
Alginate gelation-induced cell death during laser-assisted cell printing
H Gudapati, J Yan, Y Huang, DB Chrisey - Biofabrication, 2014 - iopscience.iop.org
… gelation, gelation time, alginate concentration, and laser fluence on the post-transfer cell …
gel reactant solution to form cell-laden alginate microspheres. It is found that the effects of …
gel reactant solution to form cell-laden alginate microspheres. It is found that the effects of …
Thermodynamics of gelation of sickle cell deoxyhemoglobin
PD Ross, J Hofrichter, WA Eaton - Journal of Molecular Biology, 1977 - Elsevier
… over the rangr of 0.23 to 0.28 g crne3> (2) independent of the time after gelation up to 24
hours or of the time of sedimentation up to xix hours, and (3) independent of the field strength …
hours or of the time of sedimentation up to xix hours, and (3) independent of the field strength …
Sonication-induced gelation of silk fibroin for cell encapsulation
X Wang, JA Kluge, GG Leisk, DL Kaplan - Biomaterials, 2008 - Elsevier
… Previously we reported gelation times of days to weeks for aqueous native silk … gelation
kinetics. Here we report a novel method to accelerate the process and control silk fibroin gelation …
kinetics. Here we report a novel method to accelerate the process and control silk fibroin gelation …
Gelation of sickle cell hemoglobin in mixtures with normal adult and fetal hemoglobins
HR Sunshine, J Hofrichter, WA Eaton - Journal of molecular biology, 1979 - Elsevier
… Because the kinetics of gelation appear to be under … delay time of gelation, as well as the
dependence of the delay time on … of therapeutic agents for sickle cell disease. This aspect of the …
dependence of the delay time on … of therapeutic agents for sickle cell disease. This aspect of the …
Non-ideality and the thermodynamics of sickle-cell hemoglobin gelation
AP Minton - Journal of Molecular Biology, 1977 - Elsevier
… Gelation (cessation of flow) is observed to occur at time tg (> te), … gelation proceeds, when
the advancement At/ra ---- 1 ; ie when At = ~'a. Likewise, when ra is a function of time, gelation …
the advancement At/ra ---- 1 ; ie when At = ~'a. Likewise, when ra is a function of time, gelation …
Enzymatic control of chitosan gelation for delivery of periodontal ligament cells
XZ Yan, AWG Nijhuis… - Macromolecular …, 2014 - Wiley Online Library
… was determined by inverting the vials every 30 s and the time at which the formulation did
not flow was recorded as the gelation time. This gelation time was recorded for 25 different …
not flow was recorded as the gelation time. This gelation time was recorded for 25 different …
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