Oxidized lowdensity lipoprotein induces endothelial progenitor cell senescence, leading to cellular dysfunction

T Imanishi, T Hano, T Sawamura… - Clinical and …, 2004 - Wiley Online Library
… marrow-derived endothelial progenitor cells (EPC). We investigated the effect of oxidized
low-density lipoprotein (ox-LDL) on the senescence of EPC, leading to cellular dysfunction. …

[PDF][PDF] Cellular and molecular mechanisms of endothelial cell dysfunction.

DG Harrison - The Journal of clinical investigation, 1997 - Am Soc Clin Investig
… have been shown to lower eNOS expression. Exposure of cultured endothelial cells to TNF-
, hypoxia, and high concentrations of oxidized low density lipoprotein decrease eNOS levels …

Epigenetic upregulation of p66shc mediates low-density lipoprotein cholesterol-induced endothelial cell dysfunction

YR Kim, CS Kim, A Naqvi, A Kumar… - American Journal …, 2012 - journals.physiology.org
cell dysfunction. Human LDL stimulates human p66shc promoter activity and p66shc expression
in human endothelial cells… endothelial cells and plasma coagulation on endothelial cells

LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells: implications in endothelial dysfunction and atherosclerosis

M Chen, T Masaki, T Sawamura - Pharmacology & therapeutics, 2002 - Elsevier
… As a new member of the NK cell gene … cell dysfunction. In addition, LOX-1 might also
have (patho)physiological effects on cell-cell interactions such as those exhibited by NK cell

Endothelial dysfunction, oxidation of lowdensity lipoprotein, and cardiovascular disease

P Holvoet - Therapeutic apheresis, 1999 - Wiley Online Library
… Endothelial cell dysfunction may be the consequence of increased endocytic activity in
cells … The accumulation of foam cells and smooth muscle cell proliferation cause intimal …

… miR‐512‐3p derived from mesenchymal stem cells inhibits oxidized lowdensity lipoprotein‐induced vascular endothelial cells dysfunction via regulating Keap1

S Chen, H Zhou, B Zhang, Q Hu - Journal of biochemical and …, 2021 - Wiley Online Library
Atherosclerosis (AS) is a prevalent chronic inflammatory vascular disease. Upregulated
oxidized lowdensity lipoprotein (ox‐LDL) in the serum has been found to induce endothelial …

NR3C2 mediates oxidised low-density lipoprotein-induced human coronary endothelial cells dysfunction via modulation of NLRP3 inflammasome activation

X Chen, W Li, C Chang - Autoimmunity, 2023 - Taylor & Francis
low density lipoprotein (ox-LDL)-induced inflammation in human coronary endothelial cells
(… factors IL-1β and IL-18 in the cell supernatant were evaluated by ELISA. The molecular …

Oxidized lowdensity lipoprotein promotes vascular endothelial cell dysfunction by stimulating miR‐496 expression and inhibiting the Hippo pathway effector YAP

J Hu, T Liu, Z Zhang, Y Xu, F Zhu - Cell Biology International, 2019 - Wiley Online Library
… in human umbilical vascular endothelial cells (HUVECs). At … more severe dysfunction
compared to the control cells. This in… expression and induce vascular endothelial cell dysfunction. …

Insulin-secreting β-cell dysfunction induced by human lipoproteins

ME Roehrich, V Mooser, V Lenain, J Herz… - Journal of biological …, 2003 - ASBMB
… the internalization of fluorescent low density lipoprotein (LDL) and high density lipoprotein
(HDL) particles in insulin-secreting β-cells. Purified human very low density lipoprotein (VLDL…

Apolipoprotein CIII links hyperlipidemia with vascular endothelial cell dysfunction

A Kawakami, M Osaka, M Tani, H Azuma, FM Sacks… - Circulation, 2008 - Am Heart Assoc
… in human umbilical vein endothelial cells, which was … -low-density lipoprotein impaired
insulin stimulation of NO production by vascular endothelium and induced endothelial dysfunction