… proteins, enzymes, and peptides produced by the most well-known fungi used as cell factories
… are important to consider when filamentous fungi are optimized as efficient cell factories. …

… Recombinant proteins produced in yeast are properly folded and glycosylated to a certain
extent similar to the one expressed in mammalian cells. Various human therapeutic proteins, …

… economic footprint of these cell factories ranges in the hundreds of billions of USD/year on
the global markets: pharmaceutical proteins have been estimated at 140 billion USD in 2013 ( …

… stability of production over extended … protein production stability, and considers how this
knowledge might be linked to rational approaches to enhance production from mammalian cells. …

… Moreover, CHO cells can produce proteins with a range of PTMs, including complex
disulfide patterns. Specifically in the realm of human-like glycosylation, they currently have …

… production strains. Furthermore, this technology opened the way to exploit these organisms
to produce proteins … become preferred host organisms for protein production, and discuss the …

… It is notable that in the scenario of production of secretory heterologous protein, robust
protein induction and flux might somewhat lead to lowered efficiency of secretion because of …

… host to produce secretory recombinant proteins. However, there … use as secretory recombinant
protein production hosts. In … cell factories endowed with enhanced capacities of protein …

… cell factories are employed for the bioconversion of substrates into valuable products. Cell
factories … , or a combination of native and heterologous proteins [51]. Microbes such as baker’s …

… This poses a fascinating challenge for cell factory engineering since inactivation of quality
… this important cell factory for production of cytoplasmic and secretory proteins. Nevertheless, …