… , resulting in a 10-fold reduction in CSC frequency compared with the paclitaxel only-treated …
Notch signaling in both tumor and stromal cells while reducing tumorigenic cell frequency. …

… Notch signaling is important for cell survival and selfYrenewal mechanisms of cancer stem
cells.… High stem cell frequency in acute myeloid leukemia at diagnosis predicts high minimal …

… Notch signaling is transduced at the molecular and cellular … Notch signaling, rather than the
processes that it regulates. … OFF-times (ie, frequency), vary with Notch signaling strength (ie, …

… cell transplantation of leukemic cells into over 1200 recipient animals, we found that Notch
signaling did not increase the overall frequency … mutational activation of Notch likely acts as a …

… We next estimated the frequency of Flt3 + ETP cells with B cell potential using an in vivo
limiting dilution analysis (Fig. 7c). This approach was necessary, as ETPs did not give rise to B …

… A final possibility is that Notch signaling promotes the differentiation of post-mitotic precursor
cells. We analyzed goblet cell frequency in the BrdU-labeled zone (LZ) (Fig. 4C), which …

… cells use dynamics to discriminate signaling by the ligands Dll1 and Dll4 through the Notch1
receptor. Quantitative single-cell … modulate signaling predominantly through the frequency …

… link between Notch signaling and tumor development, we have analyzed the extent of Notch
mutations in tumor cell lines, using information from the recently published Cancer Cell Line …

… We observed a similar frequency and number of Foxp3 + T reg cells in the mature CD4 +
single-positive thymocyte compartment of Foxp3 EGFPCre , Foxp3 EGFPCre Pofut1 Δ/Δ , …

… cell carcinoma (HNSCC). They identified 15 tumor-suppressor genes with activities that …
on the NOTCH signaling pathway. Given that NOTCH itself is mutated at high frequency in …