B7-H1 pathway and its role in the evasion of tumor immunity

H Dong, L Chen - Journal of molecular medicine, 2003 - Springer
… 5% of CD19 + B cells express B7-H1, although B cells are activated with cell surface Ig …
immunity [15]. Our results thus demonstrated that expression of B7-H1 evades tumor immunity, …

[HTML][HTML] Immunoregulatory role of B7-H1 in chronicity of inflammatory responses

H Dong, X Chen - Cellular & molecular immunology, 2006 - ncbi.nlm.nih.gov
… At this early stage, the target cells may express no or less B7-H1, and a rapid immune
response is warranted for a complete clearance of infection. As the infection continues, the …

Co-inhibitory role of T-cell-associated B7-H1 and B7-DC in the T-cell immune response

SK Seo, HM Seo, HY Jeong, IW Choi, YM Park… - Immunology letters, 2006 - Elsevier
… of T-cell-associated B7-H1 or B7-DC in the T-cell immune response. … of B7-H1 and B7-DC
expressed on T cells in terms of cell proliferation and cytokine production by alloreactive T cells

The expression and function of costimulatory molecules B7H and B7-H1 on colonic epithelial cells

A Nakazawa, I Dotan, J Brimnes, M Allez, L Shao… - Gastroenterology, 2004 - Elsevier
… - or B7-H1-transfected L cells and fusing immune splenocytes … b7-h1 molecules on freshly
isolated colonic epithelial cells … and B7-H1 mRNA expression in freshly isolated epithelial cells

The B7 family member B7-H3 preferentially down-regulates T helper type 1–mediated immune responses

WK Suh, BU Gajewska, H Okada, MA Gronski… - Nature …, 2003 - nature.com
… In this study, however, we show that mouse B7-H3 has a negative regulatory function in T
cell–mediated immune responses both in vitro and in vivo. B7-H3 inhibited T cell proliferation …

B7-H4, a molecule of the B7 family, negatively regulates T cell immunity

GL Sica, IH Choi, G Zhu, K Tamada, SD Wang… - Immunity, 2003 - cell.com
… -H4 transfectants (Figure 2I), although these Ig fusion proteins are able to bind cells
transfected with B7-1, B7-H2, and B7-H1, respectively (Figure 2J). Our data indicates that …

Functional expression of programmed death-ligand 1 (B7-H1) by immune cells and tumor cells

RM Gibbons Johnson, H Dong - Frontiers in immunology, 2017 - frontiersin.org
… -malignant cells may also contribute to antitumor immunity. … by immune cells in the context
of CD8 + T cell priming, … by tumor cells in regulating antitumor CD8 + T cell responses. …

Blockade of B7-H1 improves myeloid dendritic cell–mediated antitumor immunity

TJ Curiel, S Wei, H Dong, X Alvarez, P Cheng… - Nature medicine, 2003 - nature.com
B7-H1 in tumor immunity, we activated allogeneic human T cells with tumor MDCs, which
induced significant T-cell IL-10 … 2b and c ) from both CD4 + and CD8 + T cells (Fig. 2c, panel 4). …

B7-H1 up-regulation on myeloid dendritic cells significantly suppresses T cell immune function in patients with chronic hepatitis B

L Chen, Z Zhang, W Chen, Z Zhang, Y Li… - The Journal of …, 2007 - journals.aai.org
… dendritic cells contribute to inadequate adaptive immunity in … B7-H1 expression on
circulating myeloid dendritic cells (… We found that B7-H1 expression is significantly up-regulated …

Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion

H Dong, SE Strome, DR Salomao, H Tamura… - Nature medicine, 2002 - nature.com
… We confirmed expression of B7-H1 mRNA in these tumor cell lines by the reverse
transcriptase–coupled polymerase chain reaction (RT-PCR) using primers specific for human B7-H1 (…