Analysis of IL-2, IL-4 and their receptors in clonally-related cell lines derived from a patient with a progressive cutaneous T-cell lymphoproliferative disorder

MA Wasik, DC Seldin, JR Butmarc, R Gertz… - Leukemia & …, 1996 - Taylor & Francis
… T-cell lymphoproliferative disorder involving primarily the skin. No mRNA for IL-2 was found
in any of the cell lines and only one line, 2A contained mRNA for IL-4, but no IL-4 protein. In …

The role of interleukin-2 (IL-2) in the differentiatin of cytotoxic T cells: the effect of monoclonal anti-IL-2 antibody and absorption with IL-2 dependent T cell lines.

DE Kern, S Gillis, M Okada… - Journal of immunology …, 1981 - journals.aai.org
… maintain the growth of IL-2 dependent T cell line and to “help… by absorption with either
IL-2 dependent cell lines or by … 2 variables; regression analysis of points for values of IL-2 of …

Receptors for Interleukin 2 on Human Squamous Cell Carcinoma Cell Lines and Tumor in Situ

E Weidmann, M Sacchi, S Plaisance, DS Heo… - Cancer research, 1992 - AACR
… -2 of in vivoand in vitro growth of human SCCHN cell lines (24). We now report the presence
and describe the characteristics of IL… was determined by flow cytometry analysis using mAbs …

Derivation of a T cell line that is highly responsive to IL-4 and IL-2 (CT. 4R) and of an IL-2 hyporesponsive mutant of that line (CT. 4S).

J Hu-Li, J Ohara, C Watson, W Tsang… - Journal of immunology …, 1989 - journals.aai.org
… fact that T cell lines that respond to IL-4 also respond to IL-2, making the assessment of IL-4 …
We have recently begun the analysis of other specific differences in the effects of IL-4 and …

Establishment of an IL2 independent, human T‐cell line possessing only the p70 IL2 receptor

G Starkebaum, TP Loughran JR… - … journal of cancer, 1991 - Wiley Online Library
… blood cells and cultured cells, indicating that the cell line was … T-cells grew in complete
medium without added IL-2, we … However, Northern analysis of RNA from the cell line cultured …

Suppression of apoptosis in a cytotoxic T-cell line by interleukin 2-mediated gene transcription and deregulated expression of the protooncogene bcl-2.

G Deng, ER Podack - … of the National Academy of Sciences, 1993 - National Acad Sciences
… Our studies focus on apoptosis of the interleukin 2 (IL-2)dependent cell line CTLL2 induced
by IL-2 … by Northern blot analysis for up to 48 h after addition of IL-2. Endogenous 7.5-kb bcl-…

TCGF (IL 2)-receptor inducing factor (s). I. Regulation of IL 2 receptor on a natural killer-like cell line (YT cells).

J Yodoi, K Teshigawara, T Nikaido, K Fukui… - … (Baltimore, Md.: 1950 …, 1985 - journals.aai.org
… -R expression is not suitable for the analysis of fine regulation mechanism of IL 2-R … cell
line whose IL 2-R is regulated by a factor@) contained in the CM of human PBL or spleen cells. …

[PDF][PDF] Retroviral expression of the human IL2 gene in a murine T cell line results in cell growth autonomy and tumorigenicity.

G Yamada, Y Kitamura, H Sonoda, H Harada… - The EMBO …, 1987 - embopress.org
… In this analysis, the level of the IL-2 specific RNA is only 3 (… into a cultured T cell line to produce
IL-2 for the acquisition of … the IL-2 autocrine loop indeed results in the generation of T cell

Soluble interleukin 2 receptors are released from activated human lymphoid cells in vitro.

LA Rubin, CC Kurman, ME Fritz… - … (Baltimore, Md.: 1950 …, 1985 - journals.aai.org
… of both IL 2-dependent cell lines stimulated with IL 2 or PHA-… an IL 2-dependent human T
cell line was stimulated with IL 2 … An analysis of the apparent mw of soluble IL 2R from an IL 2-…

Establishment of an interleukin 2-dependent human T cell line from a patient with T cell chronic lymphocytic leukemia who is not infected with human T cell leukemia …

T Hori, T Uchiyama, M Tsudo, H Umadome, H Ohno… - 1987 - ashpublications.org
… an interleukin 2 (IL-2)-dependent human T cell line, Kit 225, from a patient with T cell chronic
lymphocytic leukemia (T-CLL) with OKT3+, -T4+, -T8- phenotype. Southern blot analysis