[HTML][HTML] Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines
… order of IC50s of mKRAS cell lines with a) all other cell lines and b) cell lines wild type for
all … cell lines which included seven of the 10 EGFR mutant cell lines, one cell line with EGFR …
all … cell lines which included seven of the 10 EGFR mutant cell lines, one cell line with EGFR …
[HTML][HTML] Impact of the 3D microenvironment on phenotype, gene expression, and EGFR inhibition of colorectal cancer cell lines
AC Luca, S Mersch, R Deenen, S Schmidt, I Messner… - PloS one, 2013 - journals.plos.org
… of EGFR in lrECM 3D cultured CRC cell lines, we hypothesized that these differences may
affect the sensitivity to EGFR kinase inhibition. To test our hypothesis, we treated CRC cells …
affect the sensitivity to EGFR kinase inhibition. To test our hypothesis, we treated CRC cells …
[HTML][HTML] Properties of resistant cells generated from lung cancer cell lines treated with EGFR inhibitors
… cases of NSCLC accompanied by mutant EGFR, treatment targeting inhibition of EGFR
kinase activity in differentiated cancer cells may generate a population of cancer cells with stem …
kinase activity in differentiated cancer cells may generate a population of cancer cells with stem …
[HTML][HTML] EGFR inhibitor enhances cisplatin sensitivity of oral squamous cell carcinoma cell lines
Y Hiraishi, T Wada, K Nakatani, I Tojyo… - Pathology & Oncology …, 2008 - Springer
… an EGFR inhibitor improves cisplatin sensitivity in oral squamous cell carcinoma (OSCC) cell
lines… The effects of a combination of AG1478, a specific EGFR tyrosine kinase inhibitor, with …
lines… The effects of a combination of AG1478, a specific EGFR tyrosine kinase inhibitor, with …
Aberrant epidermal growth factor receptor signaling and enhanced sensitivity to EGFR inhibitors in lung cancer
J Amann, S Kalyankrishna, PP Massion, JE Ohm… - Cancer research, 2005 - AACR
… cell lines for alterations in EGFR gene copy number, enhanced expression of EGFR and other
HER family members, and EGFR … NSCLC cell lines, we found that the presence of EGFR …
HER family members, and EGFR … NSCLC cell lines, we found that the presence of EGFR …
Implications of EGFR inhibition in ovarian cancer cell proliferation
SLB Phelps, JO Schorge, MJ Peyton, H Shigematsu… - Gynecologic …, 2008 - Elsevier
… cancer cells with EGFR inhibition even in cell lines that over-… (44%) ovarian cancer cell lines
express EGFR, a finding that … Over-expression of EGFR, was seen in three of four cell lines …
express EGFR, a finding that … Over-expression of EGFR, was seen in three of four cell lines …
Relationship of EGFR Mutations, Expression, Amplification, and Polymorphisms to Epidermal Growth Factor Receptor Inhibitors in the NCI60 Cell Lines
W Liu, X Wu, W Zhang, RC Montenegro… - Clinical Cancer …, 2007 - AACR
… Correlation between EGFR and cytotoxicity of EGFR inhibitors. As previously reported, the
11 EGFR inhibitors showed similar GI 50 fingerprints across the NCI60 cell line series (1). The …
11 EGFR inhibitors showed similar GI 50 fingerprints across the NCI60 cell line series (1). The …
… to mesenchymal transition derived from repeated exposure to gefitinib determines the sensitivity to EGFR inhibitors in A549, a non-small cell lung cancer cell line
JK Rho, YJ Choi, JK Lee, BY Ryoo, SH Yang, CH Kim… - Lung cancer, 2009 - Elsevier
… A549 cell line by chronic, repeated exposure to gefitinib. Compared with the A549 cells,
the A549/GR cells … the cross-resistance against other EGFR-TK inhibitors, including CL-387,758, …
the A549/GR cells … the cross-resistance against other EGFR-TK inhibitors, including CL-387,758, …
Review on EGFR inhibitors: critical updates
… EGFR inhibitors from synthetic origin with their detailed synthetic methodology and brief
biological profile. EGFR inhibitors … NSCLC cell lines and found to be potent inhibitor of EGFR…
biological profile. EGFR inhibitors … NSCLC cell lines and found to be potent inhibitor of EGFR…
An EGFR signature predicts cell line and patient sensitivity to multiple tyrosine kinase inhibitors
… that EGFR scores were predictive of sensitivity to EGFR inhibitors, Erlotinib and Gefitinib, and
a more general tyrosine kinase inhibitor (TKI), Sorafenib in lung cancer cell lines… that EGFR …
a more general tyrosine kinase inhibitor (TKI), Sorafenib in lung cancer cell lines… that EGFR …
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