Accelerated hypofractionation for early-stage non-small-cell lung cancer

PCF Cheung, LTF Yeung, V Basrur, YC Ung… - International Journal of …, 2002 - Elsevier
… The dose fractionation of 48 Gy in 12 once-daily fractions used in our study can be completed
in an overall treatment time of 16 days, assuming that RT starts on a Monday. For patients …

… phase III CHARTWEL-trial (ARO 97-1) comparing hyperfractionated-accelerated versus conventionally fractionated radiotherapy in non-small cell lung cancer  …

M Baumann, T Herrmann, R Koch… - Radiotherapy and …, 2011 - Elsevier
… For early stage NSCLC, a dose-escalated schedule applying 2 fractions of 1.8 Gy per
day appears to be equally effective compared to surgery in matched-pair analysis [16]. …

Thoracic radiotherapy in small cell lung cancer: rationale for timing and fractionation

R Arriagada, JP Pignon, T Le Chevalier - Lung Cancer, 1989 - Elsevier
… To illustrate our reasoning we will use mean values on tumor control: if we assume for high
dose RT (over 50 Gy in classical fractionation) a probability of CR of 0.8 and a probability of …

Thoracic Radiation in Limited Stage Small Cell Lung Cancer: Trends in Radiation Fractionation

M Kazemi, C Ladbury, J Liu, S Glaser, T Williams… - Clinical Lung Cancer, 2023 - Elsevier
… Thoracic radiotherapy (TRT) is standard of care for limited-stage small cell lung cancer (…
dose of 45 Gy, recent trials have suggested similar efficacy with daily fractionation (QD) to a dose

Stereotactic hypofractionated radiotherapy for stage I non-small cell lung cancer—mature results for medically inoperable patients

J Nyman, KA Johansson, U Hultén - Lung cancer, 2006 - Elsevier
… patients with stage I non-small cell lung cancer (NSCLC) are medically … fractions was used
in this study, however a lot a work remain to establish the optimal total dose and fractionation

Accelerated hypofractionated radiation therapy (AHRT) for non-small-cell lung cancer: can we leave standard fractionation?

NR de Dios, X Sanz, P Foro, I Membrive, A Reig… - Clinical and …, 2017 - Springer
… for NSCLC consists of a total dose ≥60 Gy delivered in daily fractions of 2 Gy/day for … dose
per fraction while reducing the number of sessions, an approach that is believed to limit tumor

Quantitative assessment of radiation dose and fractionation effects on normal tissue by utilizing a novel lung fibrosis index model

C Zhou, B Jones, M Moustafa, C Schwager, J Bauer… - Radiation …, 2017 - Springer
… More recently, hypofractionated stereotactic body or ablative radiation therapy (SBRT,
SABR) is increasingly used for eg, early stage non-small cell lung cancer (NSCLC) and …

Fractionated radiation severely reduces the number of CD8+ T cells and mature antigen presenting cells within lung tumors

E Reijmen, S De Mey, W De Mey, T Gevaert… - International Journal of …, 2021 - Elsevier
… -dose fractionated RT on lungs from C57BL/6 mice, challenged 2 weeks before with firefly
luciferase expressing Lewis lung carcinoma cells … -dose fractionated RT of tumor-bearing lung

Mature results of an individualized radiation dose prescription study based on normal tissue constraints in stages I to III non–small-cell lung cancer

A van Baardwijk, S Wanders, L Boersma… - Journal of Clinical …, 2010 - ascopubs.org
… The maximal allowed total tumor dose (TTD) was 79.2 Gy 26 in twice daily fractions of 1.8
Gy with an interfraction interval of at least 8 hours. To minimize the effect of accelerated …

Fractionated administration of irinotecan and cisplatin for treatment of non-small-cell lung cancer: a phase II study of Okayama Lung Cancer Study Group

H Ueoka, M Tanimoto, K Kiura, M Tabata… - … journal of cancer, 2001 - nature.com
… to reduce the dose of CPT-11, Okayama Lung Cancer Study Group planned the fractionated
… The present phase II study was planned to investigate the effectiveness of this fractionated