… are useful approaches to identifying the mechanism of gefitinib resistance … gefitinib, we
established a human non-small cell lung carcinoma subline (PC-9/ZD) that is resistant to gefitinib. …

… drug resistance is unknown. Here we report the case of a patient with EGFR-mutant,
gefitinib-responsive, advanced non–small-cell lung cancer … during treatment with gefitinib. The …

… cell lines. Our results showed gefitinib restored most sensitivity of cisplatin-resistant wtEGFR
NSCLC cells to cisplatin and support the view that EGFR-TKI may become a combined …

… The sensitivity of gefitinib resistant cell lines can be … cells were still drug resistant, suggesting
that the activation of PI3K and MEK pathways is not the only mechanism of EGFR-resistance…

… Patients with lung cancer who respond to gefitinib have been reported to … resistance to
gefitinib in initially gefitinib-sensitive patients. We describe a patient with gefitinib-resistant lung …

… –small cell lung cancers … resistance between non–small cell lung cancer and CML. We
previously reported that, in a series of 397 unselected patients with non–small cell lung cancer …

… STAT3 mediates resistance of lung cancer tissues and cells to gefitinib In order to explore
the resistance of gefitinib in lung cancer, we built gefitinib resistant A549 and PC-9 cell lines, …

… cell lines: A549, H441 (both EGFR WT and gefitinib resistant), H1666 (EGFR WT ; gefitinib
sensitive), and H3255 (EGFR L858R ; gefitinib … its response to gefitinib has been extensively …

… in acquired resistance to gefitinib. In this study, we established a gefitinib-resistant subline
(… acquired resistance to gefitinib by establishing a gefitinib-resistant cell subline from A549 …

… , why certain types of lung cancer cells are resistant to gefitinib-induced cell death. Moreover,
this notion has been further substantiated by the cell viability assay using combinational …