Predictors of the Response to Gefitinib in Refractory Non–Small Cell Lung Cancer

KS Kim, JY Jeong, YC Kim, KJ Na, YH Kim, SJ Ahn… - Clinical cancer …, 2005 - AACR
… predictors of response. Seventy patients with relapsed non–small cell lung carcinoma were
… After the drug became available commercially, 28 more patients were treated with gefitinib. …

Clinical benefit of readministration of gefitinib for initial gefitinib-responders with non-small cell lung cancer

H Yokouchi, K Yamazaki, I Kinoshita, J Konishi… - BMC cancer, 2007 - Springer
… of gefitinib responders, by analyzing the response and … lesions by gefitinib in responders
and the results of gefitinib … with, gefitinib) following temporary cessation of gefitinib upon …

Practical management of patients with non–small-cell lung cancer treated with gefitinib

NT Shah, MG Kris, W Pao, LB Tyson… - Journal of Clinical …, 2005 - ascopubs.org
… of response and toxicity in persons with lung cancer. Many of the principles of management
relevant to gefitinib are … on the use of gefitinib in patients with non–small-cell lung cancer. …

Prediction of sensitivity of advanced non-small cell lung cancers to gefitinib (Iressa, ZD1839)

S Kakiuchi, Y Daigo, N Ishikawa… - Human Molecular …, 2004 - academic.oup.com
… -tumor effects and improved symptoms and quality-of-life of a subset of patients with advanced
non-small cell lung cancer … to predict the response of NSCLC patients to gefitinib, we used …

Effect of gefitinib re-challenge to initial gefitinib responder with non-small cell lung cancer followed by chemotherapy

Y Tomizawa, Y Fujita, A Tamura, M Shirai, S Shibata… - Lung Cancer, 2010 - Elsevier
… To evaluate the efficacy of re-challenge of gefitinib to the initial gefitinib responders, we …
to initial gefitinib and re-administrated gefitinib following chemotherapy. The response rate and …

Gefitinib in patients with brain metastases from non–small-cell lung cancer: review of 15 clinical cases

Y Namba, T Kijima, S Yokota, M Niinaka… - Clinical lung cancer, 2004 - Elsevier
… (Iressa) in a patient with advanced non-small-cell lung cancer and poor performance status.
Lung … EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. …

Risk factors for interstitial lung disease and predictive factors for tumor response in patients with advanced non-small cell lung cancer treated with gefitinib

T Takano, Y Ohe, M Kusumoto, U Tateishi… - Lung cancer, 2004 - Elsevier
lung disease (ILD) has been reported in patients with non-small cell lung cancer (NSCLC)
treated with gefitinib in … advanced NSCLC who received gefitinib monotherapy. Univariate and …

Prognostic factors in previously treated non-small cell lung cancer patients with and without a positive response to the subsequent treatment with gefitinib

H Wataya, T Okamoto, R Maruyama, T Seto… - Lung Cancer, 2009 - Elsevier
… The median survival time (MST) of all patients receiving gefitinib treatment was 10 … 39
gefitinib responders and 6 months in the 92 non-responders. Among the 39 gefitinib responders, …

Overview of gefitinib in non-small cell lung cancer: an Asian perspective

H Jiang - Japanese journal of clinical oncology, 2009 - academic.oup.com
… difference was seen in the response rate to gefitinib 250 or 500 mg/day (12 versus 9%).
Median survival was 7 months with gefitinib 250 mg/day and 6 months with gefitinib 500 mg/day …

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non–small-cell lung cancer to gefitinib

TJ Lynch, DW Bell, R Sordella… - … England Journal of …, 2004 - Mass Medical Soc
… -cell lung cancer who had a response to gefitinib, those who did not have a response, and
those who had not been exposed to gefitinib… mutant proteins were expressed in cultured cells. …