… cells to gefitinib in vitro. Our results suggested that sensitivity of a given NSCLC to gefitinib
… may biologically affect drug sensitivity and survival of lung cancer cells. Our scoring system …

… -related gene expression signature were the selection of a training set of cell lines and the
… cell lines representing the extremes of gefitinib sensitivity: 5 lines were designated sensitive …

… resistance to gefitinib, we observed the sensitivity to gefitinib using Akt inhibitor, LY294002.
A549/GR cells were exposed to LY294002 alone or in combination with gefitinib. As shown …

… of drug sensitivity to gefitinib is not … of sensitivity to gefitinib using nine human lung cancer
cell lines derived from NSCLC. PC9 was the most sensitive to gefitinib of the nine NSCLC cell …

… gefitinib-sensitizing EGFR mutations activate antiapoptotic pathways involving Akt in lung
cancer cell … status of Akt is associated with gefitinib sensitivity of NSCLC patients, in terms of …

… cell line H3255, which is very sensitive to gefitinib treatment. We characterized nine NSCLC
cell … population most responsive to gefitinib identified two sensitive cell lines. Both of the …

Purpose To evaluate epidermal growth factor receptor (EGFR) mutations and copy number
as predictors of clinical outcome in patients with non–small-cell lung cancer (NSCLC) …

… for detecting these two sensitive mutations. … to gefitinib than those with the L858R mutation
(p = 0.0108). Our current data show no difference in gefitinib sensitivity and OS after gefitinib …

… resistance and select factors that determine sensitivity to gefitinib, we established a
human non-small cell lung carcinoma subline (PC-9/ZD) that is resistant to gefitinib. PC-9/ZD …

… the effect of gefitinib on EGFR autophosphorylation on Calu-3 (sensitive) and … sensitivity
to gefitinib of resistant cell lines we evaluated the effect of a combined treatment with gefitinib …