Anti-vascular endothelial growth factor monoclonals in non-small cell lung cancer

AB Sandler, DH Johnson, RS Herbst - Clinical cancer research, 2004 - AACR
… prognostic factor, whether basic fibroblast growth factor is a favorable prognostic factor, and
whether other surrogate clinical markers, potentially released by damaged endothelial cells, …

Targeting the epidermal growth factor receptor in non-small cell lung cancer

RS Herbst, PA Bunn Jr - Clinical cancer research, 2003 - AACR
… The inhibition of tumor growth seen with EGFR-TK inhibition is also accompanied by … growth
factor (VEGF), basic fibroblast growth factor (bFGF), and TGF-α, all potent inducers of tumor

Inhibitors of epidermal-growth-factor receptors: a review of clinical research with a focus on non-small-cell lung cancer

SS Sridhar, L Seymour, FA Shepherd - The lancet oncology, 2003 - thelancet.com
Despite aggressive surgical and chemotherapeutic interventions, non-small-cell lung cancer
(NSCLC) is the leading cause of cancer-related death in men and women with overall cure …

Epidermal growth factor receptors in non-small cell lung cancer

D Veale, T Ashcroft, C Marsh, GJ Gibson… - … journal of cancer, 1987 - nature.com
… -,B and is the receptor for a class of tumour growth factors (TGF-ca). The clinical correlations
… small cell lung cancers (NSCLC). They were stained for epidermal growth factor receptor (…

Vascular endothelial growth factor, platelet-derived endothelial cell growth factor and angiogenesis in non-small-cell lung cancer

KJ O'Byrne, MI Koukourakis, A Giatromanolaki… - … journal of cancer, 2000 - nature.com
… In conclusion, VEGF and PD-ECGF are important angiogenic growth factors and have
prognostic significance in NSCLC. Furthermore the study underlines the prognostic significance of …

Human squamous cell lung cancers express increased epidermal growth factor receptors.

FJ Hendler, BW Ozanne - The Journal of clinical …, 1984 - Am Soc Clin Investig
… , epidermal growth factor; EGF-R 1, a murine monoclonal epidermal growth factor receptor-…
The present study examined human lung cancer biopsy specimens for the presence of EGF …

Epidermal growth factor receptor mutations in small cell lung cancer

A Tatematsu, J Shimizu, Y Murakami, Y Horio… - Clinical Cancer …, 2008 - AACR
… It is well known that epidermal growth factor receptor (EGFR) … in some patients with small
cell lung cancers (SCLC). In this … The vast majority of epidermal growth factor receptor (EGFR) …

Epidermal growth factor receptor expression in human lung cancer cell lines

M Haeder, M Rotsch, G Bepler, C Hennig, K Havemann… - Cancer research, 1988 - AACR
Growth factor research and oncogene research are closely linked based on the hypothesis
of autocrine secretion; ie, cancer cells can produce and respond to their own growth factors (1…

Interleukin-8 stimulates cell proliferation in non-small cell lung cancer through epidermal growth factor receptor transactivation

F Luppi, AM Longo, WI De Boer, KF Rabe, PS Hiemstra - Lung cancer, 2007 - Elsevier
… non-small cell lung cancer cells, involving transactivation of the epidermal growth factor receptor
(… a central role in regulating cell proliferation and it has been therefore implicated in lung

The Fibroblast Growth Factor Receptor Inhibitor PD173074 Blocks Small Cell Lung Cancer Growth In vitro and In vivo

OE Pardo, J Latigo, RE Jeffery, E Nye, R Poulsom… - Cancer research, 2009 - AACR
… in SCLC cells. Here, we show that the selective fibroblast growth factor receptor (FGFR)
inhibitor PD173074 blocks H-510 and H-69 SCLC proliferation and clonogenic growth in a dose-…