… maintenance of chronic pain involve … cellular and molecular levels. Here, we focus on recent
studies that highlight the involvement of epigenetic mechanisms in the CNS in chronic pain …

… The mechanisms involved in the development of chronic pain are varied and complex. Pain
processes are plastic and unrelieved pain … structure involved in pain generation. Nociceptive …

… pain pathogenesis. We also review two emerging areas in chronic pain research: 1) sexually
dimorphic glial cell … for potential pain therapeutics targeting glial cell mediators as well as …

… As chronic itch and chronic pain share some common mechanisms, we also discuss the
emerging roles of chemokines and chemokine receptors in chronic itch. Targeting specific …

… of inhibitory neurons due to apoptotic cell death. Recently, forebrain structures … mechanisms
of chronic pain may lead to more specific and effective treatment strategies for chronic pain…

… , we will provide a brief overview of the mechanism by which miRNAs seem to influence
chronic pain. Sensitization of the pain pathways is brought forward by changes in the landscape …

… glial cell activations specifically in the dorsal root ganglion and spinal cord as a mechanism
possibly driving the transition to chronic pain. This has led to a focus on non-neuronal cells …

… systems for preclinical study of pain. This article reviews some of the most widely used or
promising new models for chronic pain. Partial spinal ligation, chronic constriction injury, and L5…

… The challenge will be to tease out mechanisms through which a particular behavioral … to
enhance or suppress pain, and to understand how these mechanisms contribute to chronic pain. …

… all contributed from the cell body, the neuron would need a mechanism in place to correctly
… after cellular stimulation, likely because their mRNAs are targets for signaling mechanisms to …