… loss that mimic type 1 diabetes mellitus… cell replication and maintenance of α-cell mass.
Here, we survey these developments and their therapeutic implications for patients with diabetes …

… Because type 1 diabetic patients were younger than type 2 diabetic patients, we … population
into two subgroups (C1 and C2) adjusted on the age of the corresponding diabetic patients (…

… present in type 1 diabetic patients or through inherent changes within β-cells that affect
their function in patients suffering from type 2 diabetes. Cell replacement strategies via islet …

… from nonhematologic patients. Therefore, to confirm the diabetic stem cell “mobilopathy” in
… Therefore, the low CD34 + cell count in BM aspirates from type 2 DM patients that we have …

… diabetes, as suggested by the clear increase in the fraction of mesangial cells and volume
fraction of mesangial cells with diabetes (… However, we need to study more diabetic patients to …

… Pancreases of insulin-dependent diabetic patients contain <10% of the normal p-cell mass
(42); in several cases, regions have been identified with multiple groups of surviving insulin-…

… cells and their ability to spontaneously differentiate into cells of different germ layers. Notably,
we have differentiated these patient-specific DiPS cell lines to a cell population … β-like cell. …

… of functional stem cell-derived β-cells (SC-β cells). Here we extend this approach to generate
the first SC-β cells from type 1 diabetic patients (T1D). β-cells are destroyed during T1D …

… ) was found in type 2 diabetic patients with high levels of GAD65 and/or IA… patients and
control subjects. In conclusion, in type 2 diabetic subjects ≥65 years old, the presence of islet cell …

… In the 50% of our diabetic patients who were treated with insulin, the beta-cell mass was
40% less than that of non-diabetic patients p < 0.01). Our results are also consistent with the …