Akt: a double‐edged sword in cell proliferation and genome stability

N Xu, Y Lao, Y Zhang, DA Gillespie - Journal of oncology, 2012 - Wiley Online Library
… Addition of mitogens to quiescent (G0) mammalian cells rapidly triggers a number of
biochemical signalling cascades, including the PI3K/Akt pathway, to promote cell growth through …

Low‐power laser irradiation promotes cell proliferation by activating PI3K/Akt pathway

L Zhang, D Xing, X Gao, S Wu - Journal of cellular physiology, 2009 - Wiley Online Library
cell proliferation through PI3K/Akt signaling pathway. Akt serine/threonine protein kinases
are critical for the regulation of fundamental cellular processes including cell proliferation, …

Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression

J Liang, JM Slingerland - Cell cycle, 2003 - Taylor & Francis
… PI3K pathway is protein kinase B (PKB), also known as Akt. … PI3K pathway including cell
proliferation, survival, and cellular … role of the PI3K/PKB (Akt) pathway in cell cycle progression. …

G protein‐coupled receptor‐induced Akt activity in cellular proliferation and apoptosis

DC New, K Wu, AWS Kwok, YH Wong - The FEBS journal, 2007 - Wiley Online Library
Akt pathways are also activated by a similar method of transactivation [25]. In Swiss 3T3 cells,
bradykinin and bombesin promote cellular proliferation … activates PI3K/Akt cascades [26]. A …

PKB/Akt: a key mediator of cell proliferation, survival and insulin responses?

MA Lawlor, DR Alessi - Journal of cell science, 2001 - journals.biologists.com
… The serine/threonine protein kinase PKB (also known as Akt) … progression by stimulating
cell proliferation and inhibiting … pathway in Drosophila has been shown to markedly reduce …

Palmitic acid inhibits prostate cancer cell proliferation and metastasis by suppressing the PI3K/Akt pathway

S Zhu, W Jiao, Y Xu, L Hou, H Li, J Shao, X Zhang… - Life Sciences, 2021 - Elsevier
… Since palmitic acid was demonstrated to inhibit prostate cancer cell proliferation, we next
examined whether it would affect cell cycle progression in PC3 and DU145 cells. The cells

ILK promotes cell proliferation in breast cancer cells by activating the PI3K/Akt pathway

Y Qu, C Hao, J Xu, Z Cheng… - Molecular Medicine …, 2017 - spandidos-publications.com
… demonstrated that ILK facilitated cell proliferation in breast cancer cells through activating
the PI3K/Akt pathway, suggesting a vital role of ILK in breast cancer cell growth. The present …

[PDF][PDF] Inhibition of endothelial cell proliferation by Notch1 signaling is mediated by repressing MAPK and PI3K/Akt pathways and requires MAML1

ZJ Liu, M Xiao, K Balint, A Soma, CC Pinnix… - The FASEB …, 2006 - researchgate.net
… Similar effects were observed in HIAEC cells. Taken … pathway activation inhibits endothelial
cell proliferation by concurrently regulating both the MAPK and PI3K/Akt signaling pathways. …

… inhibits cell proliferation, promotes cell apoptosis, and induces cell cycle arrest via downregulating the PI3K/AKT/hTERT pathway in lung adenocarcinoma A549 cells

XX Lu, LY Cao, X Chen, J Xiao, Y Zou… - BioMed research …, 2016 - Wiley Online Library
… in various carcinoma models, we presumed that the PI3K/AKT pathway might be implicated
in the … AKT (p-AKT) were reduced and that cell proliferation was inhibited in A549 cells

Acemannan accelerates cell proliferation and skin wound healing through AKT/mTOR signaling pathway

W Xing, W Guo, CH Zou, TT Fu, XY Li, M Zhu… - Journal of …, 2015 - Elsevier
… -induced cell proliferation and cyclin D1 … the AKT/mTOR signaling pathway To further
confirm that acemannan promoted cyclin D1 protein translation by AKT/mTOR signaling pathway, …