Cell entry by SARS-CoV-2

R Peng, LA Wu, Q Wang, J Qi, GF Gao - Trends in biochemical sciences, 2021 - cell.com
… This process is executed by the S protein on the envelope of SARS-CoV-2, which recognizes
the host cell receptor and mediates membrane fusion to allow the viral genome to be …

Cell entry mechanisms of SARS-CoV-2

J Shang, Y Wan, C Luo, G Ye, Q Geng… - Proceedings of the …, 2020 - National Acad Sciences
… human ACE2 (hACE2) through its receptor-binding domain (… receptor binding and protease
activation of SARS-CoV-2 spike … the receptor binding and protease activations of SARS-CoV-…

ACE2: the major cell entry receptor for SARS-CoV-2

F Scialo, A Daniele, F Amato, L Pastore, MG Matera… - Lung, 2020 - Springer
receptor of SARS-CoV-2. We will discuss its biology, tissue expression, and post-translational
regulation that determine its potential to be employed by SARS-CoV-2 for cellSARS-CoV-…

VDJdb in the pandemic era: a compendium of T cell receptors specific for SARS-CoV-2

M Goncharov, D Bagaev, D Shcherbinin, I Zvyagin… - Nature …, 2022 - nature.com
… sequences recognizing dozens of SARS-CoV-2 epitopes. … SARS-CoV-2-specific T cells
and the discovery of immune signatures associated with protection against COVID-19. T cell

[HTML][HTML] Mechanisms of SARS-CoV-2 entry into cells

CB Jackson, M Farzan, B Chen, H Choe - … reviews Molecular cell …, 2022 - nature.com
… the structural and cellular foundations for understanding the multistep SARS-CoV-2 entry …
2,3,4,5,6 ; ACE2 was originally identified in 2003 as the receptor for SARS-CoV 7 . ACE2 is …

Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues

MY Li, L Li, Y Zhang, XS Wang - Infectious diseases of poverty, 2020 - mednexus.org
… We analyzed the expression of ACE2, the gene encoding the human host cell receptor of
SARS-CoV-2 and SARS-CoV, in 31 normal human tissues. To the best of our knowledge, this …

Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses

M Letko, A Marzi, V Munster - Nature microbiology, 2020 - nature.com
… as SARS-CoV and the recent SARS-CoV-2, for receptor usage and their ability to infect cell
… We then infected baby hamster kidney (BHK) cells expressing the receptor for SARS-CoV or …

Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2

Y Gu, J Cao, X Zhang, H Gao, Y Wang, J Wang, J He… - Cell research, 2022 - nature.com
… ligand-receptor interactions. Based on this method, we developed a high-throughput receptor
profiling … human membrane proteins and used it to identify SARS-CoV-2 cellular receptors. …

[HTML][HTML] SARS-CoV-2 epitopes are recognized by a public and diverse repertoire of human T cell receptors

AS Shomuradova, MS Vagida, SA Sheetikov… - Immunity, 2020 - cell.com
receptor (TCR) motifs with germline-encoded features. Bulk CD4 + and CD8 + T cell responses
to … Overall, our results demonstrate that the T cell response to SARS-CoV-2, including the …

Functional characterization of CD4+ T cell receptors crossreactive for SARS-CoV-2 and endemic coronaviruses

AG Dykema, B Zhang, BA Woldemeskel… - The Journal of …, 2021 - Am Soc Clin Investig
cells that target SARS-CoV-2. To address the hypothesis that the same CD4 + T cell clonotypes
recognize both SARS-CoV-… detect S protein–specific T cell clones in the peripheral blood …