… behavior of single molecules and ultimately relate it to cellular function. Overall, our premise
is that at these scales, cell signaling should be thought of not primarily as a sequence of …

… engineer cellular networks we need to learn how to engineer individual signaling proteins …
We postulate that much of the functional innovation in cellular signaling networks has evolved …

… ], neuronal cells [27], endothelial cells [28], and epithelial cells [… and related cellular signaling
networks are involved in … IRAK family proteins within the cellular signaling network and their …

… Second, we examine the cell signaling nodes that were most significantly altered in one or …
) for each PBMC cell subtype. Finally, we explore putative alterations in cell signaling network …

… For the PC12 cell signaling network, we have hypothesized that the left arm of the pathway
(see figure 1) is suppressing Erk1/2 activation by EGF. However, what do we predict when …

… , biochemistry, molecular biology and pathology of cellular effectors. Contains over 350
chapters of comprehensive coverage on cell signaling Includes discussion on topics from ligand/…

… curated in databases such as the Alliance for Cellular Signaling (AfCS) Molecule Pages,
which will serve as vital tools for the reconstruction and analysis of cellular signaling networks. …

… is in increasing signal specificity. We also examine the effect of noise in stochastic signaling
networks; we prove that the specificity and fidelity of linear and nonlinear networks is not …

… signaling network that potentially possesses a learning capability at multiple levels. As the
major hypothesis of our paper, we propose that, in signaling networks, cellular … in cell signaling…

… As a modular platform for engineering new, orthogonal cell-cell signaling networks, we
focused on using the synthetic notch (synNotch) receptor system (Fig. 1A). SynNotch receptors …