Bayesian network approach to cell signaling pathway modeling

K Sachs, D Gifford, T Jaakkola, P Sorger… - Science's …, 2002 - science.org
cellular signaling pathways is an emerging field. Sachs et al. illustrate the application of
Bayesian networks to an example cellular … (FAK) and extracellular signal-regulated kinase (ERK) …

[HTML][HTML] Signaling networks that link cell proliferation and cell fate

RC Sears, JR Nevins - Journal of Biological Chemistry, 2002 - ASBMB
The maintenance of normal cell function and tissue homeostasis is dependent on the precise
regulation of multiple signaling pathways that control cellular decisions to either proliferate, …

[HTML][HTML] Meta-analysis of retrograde signaling in Arabidopsis thaliana reveals a core module of genes embedded in complex cellular signaling networks

C Gläßer, G Haberer, I Finkemeier, T Pfannschmidt… - Molecular Plant, 2014 - cell.com
… as secondary components involved in the response cascades following a plastidial signal.
Our … -to-nucleus signaling and a new view on this complex cellular communication network. …

Cell-cell signaling during synapse formation in the CNS

P Scheiffele - Annual review of neuroscience, 2003 - annualreviews.org
… Synapses join individual nerve cells into a functional network. Specificcell-cell signaling
events regulate synapse formation during development andthereby generate a highly …

Systematic analysis of quantitative logic model ensembles predicts drug combination effects on cell signaling networks

MK Morris, DC Clarke, LC Osimiri… - CPT …, 2016 - Wiley Online Library
… We conclude that systematic modeling of signaling networks using CFL-Q2LM is a promising
approach for ascertaining combination anticancer therapies in diverse microenvironments. …

Noise in cellular signaling pathways: causes and effects

JE Ladbury, ST Arold - Trends in biochemical sciences, 2012 - cell.com
cellular outcomes remain poorly understood. Here, we argue that noise in signaling networks
… shaped cellular signal transduction. Features promoted by the presence of this molecular …

Lipid mediator networks in cell signaling: update and impact of cytokines1

CN Serhan, JZ Haeggström, CC Leslie - The FASEB Journal, 1996 - Wiley Online Library
Biomembranee serve barrier functions and serve as a store for precursors of rapidly
generated, structurally diverse intracellular and extracellular lipid‐derived mediators (LM). Cell

The T-cell-receptor signaling network

M Huse - Journal of cell science, 2009 - journals.biologists.com
… TCR signaling network is such that it has become a model system for complex cellular responses
… phase of T-cell signaling when activated by their respective ligands. ICOS enhances T-…

HCMV-encoded G-protein-coupled receptors as constitutively active modulators of cellular signaling networks

HF Vischer, R Leurs, MJ Smit - Trends in pharmacological sciences, 2006 - cell.com
cellular signaling, the HCMV-encoded GPCRs appear to be prime candidates for the
observed increase of cellular signaling … , redirect cellular signaling networks, modulate cellular

Ensemble modeling for analysis of cell signaling dynamics

L Kuepfer, M Peter, U Sauer, J Stelling - Nature biotechnology, 2007 - nature.com
… Here, we propose an approach to ensemble modeling of complex cellular networks that
takes structural diversity of mechanistic dynamic models into account. It relies on systematically …