The complexity of cell signaling and the need for a new mechanics
WS Hlavacek, JR Faeder - Science signaling, 2009 - science.org
… cellular behavior. To make further progress in the treatment of diseases caused by … cell
signaling, we are faced with the challenge of obtaining a predictive understanding of cellular …
signaling, we are faced with the challenge of obtaining a predictive understanding of cellular …
[HTML][HTML] Cell signaling by receptor tyrosine kinases
J Schlessinger - Cell, 2000 - cell.com
… RTKs play an important role in the control of most fundamental cellular processes including
the cell cycle, cell migration, cell metabolism and survival, as well as cell proliferation and …
the cell cycle, cell migration, cell metabolism and survival, as well as cell proliferation and …
Apigenin, a plant flavone playing Noble roles in Cancer prevention via modulation of key cell signaling networks
… cell signaling pathways that control cell homeostasis, proliferation, motility, and survival in
normal cells. … targets of apigenin and how it modulates the critical cell signaling pathways. …
normal cells. … targets of apigenin and how it modulates the critical cell signaling pathways. …
[HTML][HTML] The JAK-STAT signaling network in the human B-cell: an extreme signaling pathway analysis
JA Papin, BO Palsson - Biophysical journal, 2004 - cell.com
… Extreme signaling pathway analysis is a topologically based approach and assumes a
balanced use of the signaling network. As large-scale reconstructions of signaling networks …
balanced use of the signaling network. As large-scale reconstructions of signaling networks …
Cell signaling regulation by protein phosphorylation: a multivariate, heterogeneous, and context-dependent process
EK Day, NG Sosale, MJ Lazzara - Current opinion in biotechnology, 2016 - Elsevier
… signaling network level and identify off-target effects [52]. Because detection is based on
metal tags, many more signals can be resolved than with fluorescence approaches and without …
metal tags, many more signals can be resolved than with fluorescence approaches and without …
Bayesian inference of signaling network topology in a cancer cell line
… protein array technology with dynamic network inference to shed light on signaling networks
in samples of interest. We apply these approaches to the breast cancer cell line MDA-MB-…
in samples of interest. We apply these approaches to the breast cancer cell line MDA-MB-…
Modularity and predictability in cell signaling and decision making
O Atay, JM Skotheim - Molecular biology of the cell, 2014 - Am Soc Cell Biol
… the mechanisms of cellular decisions that specify distinct cell types, but … cell signaling will
be an emerging theme in this decade, as even the classical vertebrate morphogen TGF-β signal…
be an emerging theme in this decade, as even the classical vertebrate morphogen TGF-β signal…
Inter-cellular signaling network reveals a mechanistic transition in tumor microenvironment
… -cellular signaling network in human glioblastoma to assess the collective role of cytokine
network in … This model comprises five types of cells, fifteen signaling proteins and 69 signaling …
network in … This model comprises five types of cells, fifteen signaling proteins and 69 signaling …
Rule‐based modeling: a computational approach for studying biomolecular site dynamics in cell signaling systems
… and signaling, which are interdependent.37 We focus here on networks that mediate intracellular
signaling, … stimuli and processing of this information to yield a cellular response. These …
signaling, … stimuli and processing of this information to yield a cellular response. These …
The miRNA network: Micro-regulator of cell signaling in cancer
Q Mei, X Li, M Guo, X Fu, W Han - Expert Review of Anticancer …, 2014 - Taylor & Francis
… levels with cancer-related signaling pathways. Our understanding of … network has been
extended to include classical cell signaling, termed miRNA network complements cell signaling …
extended to include classical cell signaling, termed miRNA network complements cell signaling …