Modeling cell signaling networks

NJ Eungdamrong, R Iyengar - Biology of the Cell, 2004 - Elsevier
ODE refers to the fact that concentration is only a function of time, not space. The advantage
of ODE-… with large number of coupled nonlinear ODEs are well developed (see Box 1). For …

Spatial modeling of cell signaling networks

AE Cowan, II Moraru, JC Schaff, BM Slepchenko… - Methods in cell …, 2012 - Elsevier
… of ordinary differential equations (ODEs) describing all the changes in species concentrations
as a result of reactions or membrane transport processes. By definition, an ODE … in ODE

[HTML][HTML] Modeling approaches for qualitative and semi-quantitative analysis of cellular signaling networks

R Samaga, S Klamt - Cell communication and signaling, 2013 - Springer
… Finally, as a third formalism, Boolean networks can be transformed into logic-based ODEs
… graphs to cellular signaling networks such as the identification of signaling pathways and …

Logic-based models for the analysis of cell signaling networks

MK Morris, J Saez-Rodriguez, PK Sorger… - Biochemistry, 2010 - ACS Publications
Computational models are increasingly used to analyze the operation of complex biochemical
networks, including those involved in cell signaling networks. Here we review recent …

Modeling of signaling networks

SR Neves, R Iyengar - Bioessays, 2002 - Wiley Online Library
… Virtual Cell uses two separate numerical solvers: one for their kinetic modeling that uses
Ordinary Differential Equations (ODEs) … The output of data in Virtual Cell is in different formats: …

A framework for inference and selection of cell signaling pathway dynamic models

M Batista, F Montoni, C Campos, R Nogueira… - Brazilian Symposium on …, 2023 - Springer
… communication is the usage of ODE systems coupled with neural networks, which can be …
approach tailored for UDE-based cell signaling pathway modeling that consolidates these …

Tools to analyse cell signaling models

DM Collins - 2004 - dspace.mit.edu
cell signaling. In particular, we are interested in developing tools to characterize the qualitative
behavior of the epidermal growth factor cell signaling network. … properties of ODE models …

A Framework for Inference and Selection of Cell Signaling Pathway Dynamic Models

R Nogueira, HA Armelin, MS Reis - LNBI 13954 - Springer
… for universal differential equation UDE-based cell signaling pathway modeling. The open-source…
will enable researchers to design improved cell signaling pathway models more easily, …

A comprehensive statistical model for cell signaling

E Yoruk, MF Ochs, D Geman… - IEEE/ACM Transactions …, 2010 - ieeexplore.ieee.org
Protein signaling networks play a central role in … Bayesian networks, have been widely used
to model cell signaling, … observable components of signaling. Specifically, we account for …

[HTML][HTML] Systematic calibration of a cell signaling network model

KA Kim, SL Spencer, JG Albeck, JM Burke… - BMC …, 2010 - Springer
… -induced cell death signaling [7]. This model is composed of ordinary differential equations
… Although most ODE models assume simply that the inside of cell is a mixed soup and do not …