… with cancer development, and progression and overexpression of HER2 has been found in
… mechanistic understanding of the underlying cellular signaling networks, both for improved …

… to cell signaling in eukaryotes, the focus of this review, complex multicomponent networks
… to determine the effects of protein overexpression or inhibition on phenotype, elucidate …

… signal transduction research and contributed significantly to the understanding of cell
signaling networks. … Indeed, we reported that overexpression of the IDH1 mutant, which causes …

… limit cell proliferation, such as apoptosis and replicative senescence. These properties reflect
alterations in the cellular signaling pathways that in normal cells control cell … are signaling …

… of MDM2 in human cancers suggests that the protein confers a survival advantage to cancer
cells. However, overexpression of MDM2 in normal cells seems to restrict cell proliferation. …

… -cell signaling network profiling … network characterization using single-cell data and
discuss potential confounding factors that need to be considered in single-cell signaling network …

… levels with cancer-related signaling pathways. Our understanding of … network has been
extended to include classical cell signaling, termed miRNA network complements cell signaling …

… c-Myc transcription factor, and the Ras signaling molecule, followed by recent work showing
… picture of the network controlling the balance between cellular proliferation and apoptosis. …

… as a link between signaling pathways and gene regulation. Cell signaling tends to result in
the modulation of a set of TFs that then lead to changes in the cell's transcriptional program. …

… actions in many aspects including cell growth, differentiation, apoptosis and cellular responses
to external stresses. Lots of evidence has indicated that overexpression and activation of …