… We used modular decomposition to analyze a large PCP protein-protein interaction network
of experimental data. It helped to structure the whole network in a consistent way but was …

… PM) in particular, offer unique local environments for effective protein–protein interactions
and therefore serve as the main sites for protein complexes and networks 1,2,3 . Accumulating …

… of stochastic fluctuation of protein concentration on protein–protein interactions, which form
the basis of the majority of biological signaling pathways. In particular, very little is known …

… it to cellular function. Overall, our premise is that at these scales, cell signaling should be …
The hallmarks of protein–protein interactions resemble those present within protein cores […

… They share the presence in protein structure of a specific TRAF domain which function is
protein-protein interaction. It binds to receptors by its N-extremity (TRAF-N domain) and to …

… pathway by performing coexpression clustering analysis of large-scale gene expression
data in combination with information on pairwise protein–protein interaction. As mentioned …

… interconnected pathways. In general, genomics and high-throughput studies support the
less modular view of cell signaling. Specifically, interaction maps based on protein–protein …

… Formation of an oligomeric protein or engagement in the temporary protein–protein
interactions within the signaling network would require a new level of inter-subunit interactions, …

… In our final section, we discuss how the critical roles for JNK signaling in mammals help
to explain why microbes often “tinker” with JNK signaling pathways to use them to their own …

… Signaling networks have evolved to respond to distinct environmental stimuli with …
signaling enzymes in the cell, form a highly connected and perhaps irreducibly complex network …